ムーンショット型研究開発事業 目標2:2050年までに超早期に疾患の予測・予防をすることができる社会を実現 恒常性の理解と制御による糖尿病および併発疾患の克服 プロジェクトマネージャー(PM):片桐秀樹(東北大学大学院医学系研究科 教授)

研究成果

2022 | 2021 | 2020

2022

原著論文

  • Nonaka H, Ohue-Kitano R, Masujima Y, Igarashi M, Kimura I.
    Dietary medium-chain triglyceride decanoate affects glucose homeostasis through GPR84-mediated GLP-1 secretion in mice. Front Nutr 9:e848450, 2022. https://doi.org/10.3389/fnut.2022.848450
  • Yakubo K, Fujiki Y.
    A general model of hierarchical fractal scale-free networks. PLoS One 17(3):e0264589, 2022. https://doi.org/10.1371/journal.pone.0264589
  • Zheng K, Smith JS, Eiger DS, Warman A, Choi I, Honeycutt CC, Boldizsar N, Gundry JN, Pack TF, Inoue A, Caron MG, Rajagopal S.
    Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes. Sci Signal 15(726):eabg5203, 2022. https://doi.org/10.1126/scisignal.abg5203
  • Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y.
    Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat Chem Biol 18(3):281-288, 2022. https://doi.org/10.1038/s41589-021-00930-3
  • Yuzawa R, Koike H, Manabe I, Oishi Y.
    VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes. Sci Rep 12(1):1377, 2022. https://doi.org/10.1038/s41598-022-05354-0
  • Yasugahira Y, Nagayama M.
    On a numerical bifurcation analysis of a particle reaction‐diffusion model for a motion of two self‐propelled disks. Jpn J Ind Appl Math 1-22, 2022. https://doi.org/10.1007/s13160-021-00498-4
  • Kawakami K, Yanagawa M, Hiratsuka S, Yoshida M, Ono Y, Hiroshima M, Ueda M, Aoki J, Sako Y, Inoue A.
    Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias. Nat Commun 13(1):487, 2022. https://doi.org/10.1038/s41467-022-28056-7
  • Iio K, Kutsumura N, Nagumo Y, Saitoh T, Tokuda A, Hashimoto K, Yamamoto N, Kise R, Inoue A, Mizoguchi H, Nagase H.
    Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands. Bioorg Med Chem Lett 56:128485, 2022. https://doi.org/10.1016/j.bmcl.2021.128485

総説

  • Morrison SF, Nakamura K, Tupone D.
    Thermoregulation in mice: The road to understanding torpor hypothermia and the shortcomings of a circuit for generating fever. Temperature 2022. https://doi.org/10.1080/23328940.2021.2021059
  • Imai J, Katagiri H.
    Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation. Int Immunol 34(2):67-79, 2022. https://doi.org/10.1093/intimm/dxab023

2021

原著論文

  • Kume S.
    Ketone bodies: back to a place in the sun. Kidney Int 100(5):976-978, 2021. https://doi.org/10.1016/j.kint.2021.07.022
  • Pandey S, Kumari P, Baidya M, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li XX, Cui CS, Lee JD, Kawakami K, Chaturvedi M, Ranjan A, Laporte SA, Woodruff TM, Inoue A, Shukla AK.
    Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Mol Cell 81(18):1-17, 2021. https://doi.org/10.1016/j.molcel.2021.09.007
  • Liu L, Koike H, Ono T, Hayashi S, Kudo F, Kaneda A, Kagechika H, Manabe I, Nakashima T, Oishi Y.
    Identification of a novel KLF5-dependent program and drug development for skeletal muscle atrophy. Proc Natl Acad Sci U S A 118(35):e2102895118, 2021. https://doi.org/10.1073/pnas.2102895118
  • Watanabe K, Yamano M, Masujima Y, Ohue-Kitano R, Kimura I.
    Curdlan intake changes gut microbial composition, short-chain fatty acid production, and bile acid transformation in mice. Biochem Biophys Rep 27:101095, 2021. https://doi.org/10.1016/j.bbrep.2021.101095
  • McGlone ER, Manchanda Y, Jones B, Pickford P, Inoue A, Carling D, Bloom SR, Tan T, Tomas A.
    Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling. Mol Metab 53:101296, 2021. https://doi.org/10.1016/j.molmet.2021.101296
  • Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M, Crown SB, Osawa T, Sakai J, McGarrah RW, White PJ, Nakamura K, Kajimura S.
    Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. Elife 10:e66865, 2021. https://doi.org/10.7554/eLife.66865
  • Chiba H.
    A Hopf bifurcation in the Kuramoto-Daido model. J Diff Equ 280:545-570, 2021. https://doi.org/10.1016/j.jde.2021.01.024
  • Kubota SI, Takahashi K, Mano T, Matsumoto K, Katsumata T, Shi S, Tainaka K, Ueda HR, Ehata S, Miyazono K.
    Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing. Commun Biol 4(1):294, 2021. https://doi.org/10.1038/s42003-021-01786-y
  • Iwama T, Kano K, Saigusa D, Ekroos K, van Echten-Deckert G, Vogt J, Aoki J.
    Development of an On-Tissue Derivatization Method for MALDI Mass Spectrometry Imaging of Bioactive Lipids Containing Phosphate Monoester Using Phos-tag. Anal Chem 93(8):3867-3875, 2021. https://doi.org/10.1021/acs.analchem.0c04479
  • Adachi Y, Ota K, Minami I, Yamada T, Watanabe T.
    Lower Insulin Secretion Is Associated with Hippocampal and Parahippocampal Gyrus Atrophy in Elderly Patients with Type 2 Diabetes Mellitus. J Diabetes Investig 12(10):1908-1913, 2021. https://doi.org/10.1111/jdi.13554
  • Nakamaru R, Yamamoto K, Akasaka H, Rakugi H, Kurihara I, Yoneda T, Ichijo T, Katabami T, Tsuiki M, Wada N, Yamada T, Kobayashi H, Tamura K, Ogawa Y, Kawashima J, Inagaki N, Fujita M, Watanabe M, Kamemura K, Okamura S, Tanabe A, Naruse M; JPAS/JRAS Study Group.
    Age-stratified comparison of clinical outcomes between medical and surgical treatments in patients with unilateral primary aldosteronism. Sci Rep 11(1):6925, 2021. https://doi.org/10.1038/s41598-021-86290-3
  • Kotani K, Akao A, Chiba H.
    Bifurcation of the neuronal population dynamics of the modified theta model: transition to macroscopic gamma oscillation. Physica D 416:132789, 2021. https://doi.org/10.1016/j.physd.2020.132789
  • Fukuda T, Bouchi R, Takeuchi T, Amo-Shiinoki K, Kudo A, Tanaka S, Tanabe M, Akashi T, Hirayama K, Odamaki T, Igarashi M, Kimura I, Tanabe K, Tanizawa Y, Yamada T, Ogawa Y.
    Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes. Diabetes Care 44(4):1002-1011, 2021. https://doi.org/10.2337/dc20-0864
  • Nakamaru R, Yamamoto K, Akasaka H, Rakugi H, Kurihara I, Yoneda T, Ichijo T, Katabami T, Tsuiki M, Wada N, Yamada T, Kobayashi H, Tamura K, Ogawa Y, Kawashima J, Inagaki N, Fujita M, Oki K, Kamemura K, Tanabe A, Naruse M; JPAS/JRAS study group.
    Sex Differences in Renal Outcomes After Medical Treatment for Bilateral Primary Aldosteronism. Hypertension 77(2):537-545, 2021. https://doi.org/10.1161/HYPERTENSIONAHA.120.16449
  • Kano K, Matsumoto H, Kono N, Kurano M, Yatomi Y, Aoki J.
    Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification. J Lipid Res 62:100029, 2021. https://doi.org/10.1016/j.jlr.2021.100029
  • Amo-Shiinoki K, Tanabe K, Hoshii Y, Matsui H, Harano R, Fukuda T, Takeuchi T, Bouchi R, Takagi T, Hatanaka M, Takeda K, Okuya S, Nishimura W, Kudo A, Tanaka S, Tanabe M, Akashi T, Yamada T, Ogawa Y, Ikeda E, Nagano H, Tanizawa Y. Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes. JCI Insight 6(1):e143791, 2021. https://doi.org/10.1172/jci.insight.143791
  • Bouchi R, Sonoda N, Itoh J, Ono Y, Fukuda T, Takeuchi T, Kishimoto J, Yamada T, Ogawa Y.
    Effects of intensive exercise combined with dapagliflozin on body composition in patients with type 2 diabetes: a randomized controlled trial. Endocr J 68(3):329-343, 2021. https://doi.org/10.1507/endocrj.EJ20-0599

総説

2020

原著論文

  • Kawahori K, Kondo Y, Yuan X, Kawasaki Y, Hanzawa N, Tsujimoto K, Wada F, Kohda T, Ishigami A, Yamada T, Ogawa Y, Hashimoto K.
    Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver. Sci Rep 10(1):21228, 2020. https://doi.org/10.1038/s41598-020-77962-7

ムーンショット型研究開発事業 目標2:2050年までに超早期に疾患の予測・予防をすることができる社会を実現
恒常性の理解と制御による糖尿病および併発疾患の克服
プロジェクトマネージャー(PM):片桐秀樹(東北大学大学院医学系研究科 教授)
プロジェクトに関する問い合わせ先: moonshot-katagiri@proj.med.tohoku.ac.jp

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