研究成果

2023 | 2022 | 2021 | 2020

2023

原著論文

Yahiro T, Kataoka N, Nakamura K.
Two Ascending Thermosensory Pathways from the Lateral Parabrachial Nucleus That Mediate Behavioral and Autonomous Thermoregulation.
J Neurosci 43(28):5221-5240, 2023.
https://doi.org/10.1523/JNEUROSCI.0643-23.2023
Sugawara H, Imai J, Yamamoto J, Izumi T, Kawana Y, Endo A, Kohata M, Seike J, Kubo H, Komamura H, Munakata Y, Asai Y, Hosaka S, Sawada S, Kodama S, Takahashi K, Kaneko K, Katagiri H.
A highly sensitive strategy for monitoring real-time proliferation of targeted cell types in vivo.
Nat Commun 14:3253, 2023.
https://doi.org/10.1038/s41467-023-38897-5
Tomita I, Tsuruta H, Yasuda-Yamahara M, Yamahara K, Kuwagata S, Tanaka-Sasaki Y, Chin-Kanasaki M, Fujita Y, Nishi E, Katagiri H, Maegawa H, Kume S.
Ketone bodies: A double-edged sword for mammalian life span.
Aging Cell 22(6):e13833, 2023.
https://doi.org/10.1111/acel.13833
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM.
Molecular mechanism of fatty acid activation of FFAR1.
Proc Natl Acad Sci U S A 120(22):e2219569120, 2023.
https://doi.org/10.1073/pnas.2219569120
Ogawa A, Ohira S, Kato Y, Ikuta T, Yanagida S, Mi X, Ishii Y, Kanda Y, Nishida M, Inoue A, Wei FY.
Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.
Commun Biol 6(1):511, 2023.
https://doi.org/10.1038/s42003-023-04888-x
Takahashi K, Yamada T, Hosaka S, Kaneko K, Asai Y, Munakata Y, Seike J, Horiuchi T, Kodama S, Izumi T, Sawada S, Hoshikawa K, Inoue J, Masamune A, Ueno Y, Imai J, Katagiri H.
Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages.
Cell Rep 42(5):112415, 2023.
https://doi.org/10.1016/j.celrep.2023.112415
Niitsu Y, Komiya C, Takeuchi A, Hara K, Horino M, Aoki J, Okazaki R, Murakami M, Tsujimoto K, Ikeda K, Yamada T.
Increased serum extracellular vesicle miR-144-3p and miR-486a-3p in a mouse model of adipose tissue regeneration promote hepatocyte proliferation by targeting Txnip.
PLoS One 18(5):e0284989, 2023.
https://doi.org/10.1371/journal.pone.0284989
Watanabe A, Koike H, Kumagami N, Shimba S, Manabe I, Oishi Y.
Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair.
Sci Rep 13(1):6747, 2023.
https://doi.org/10.1038/s41598-023-33830-8
Iio K, Hashimoto K, Nagumo Y, Amezawa M, Hasegawa T, Yamamoto N, Kutsumura N, Takeuchi K, Ishikawa Y, Yamamoto H, Tokuda A, Sato T, Uchida Y, Inoue A, Tanimura R, Yanagisawa M, Nagase H, Saitoh T.
Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
J Med Chem 66(8):5453-5464, 2023.
https://doi.org/10.1021/acs.jmedchem.2c01773
Heng J, Hu Y, Perez-Hernandez G, Inoue A, Zhao J, Ma X, Sun X, Kawakami K, Ikuta T, Ding J, Yang Y, Zhang L, Peng S, Niu X, Li H, Guixa-Gonzalez R, Jin C, Hildebrand PW, Chen C, Kobilka BK.
Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor.
Nat Commun 14(1):2005, 2023.
https://doi.org/10.1038/s41467-023-37233-1
Kjar VMS, Daugvilaite V, Stepniewski TM, Madsen CM, Jorgensen AS, Bhuskute KR, Inoue A, Ulven T, Benned-Jensen T, Hjorth SA, Hjorto GM, Moo EV, Selent J, Rosenkilde MM.
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization.
Sci Signal 16(779):eabl4283, 2023.
https://doi.org/10.1126/scisignal.abl4283
Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G.
Insights into distinct signaling profiles of the μOR activated by diverse agonists.
Nat Chem Biol 19(4):423-430, 2023.
https://doi.org/10.1038/s41589-022-01208-y
Tsuji S, Brace CS, Yao R, Tanie Y, Tada H, Rensing N, Mizuno S, Almunia J, Kong Y, Nakamura K, Furukawa T, Ogiso N, Toyokuni S, Takahashi S, Wong M, Imai SI, Satoh A.
Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice.
Life Sci Alliance 6(6):e202301992, 2023.
https://doi.org/10.26508/lsa.202301992
Garami A, Steiner AA, Pakai E, Wanner SP, Almeida MC, Keringer P, Oliveira DL, Nakamura K, Morrison SF, Romanovsky AA.
The neural pathway of the hyperthermic response to antagonists of the transient receptor potential vanilloid-1 channel.
Temperature 10(1):136-154, 2023.
https://doi.org/10.1080/23328940.2023.2171671
Shirai T, Nakai A, Ando E, Fujimoto J, Leach S, Arimori T, Higo D, van Eerden FJ, Tulyeu J, Liu YC, Okuzaki D, Murayama MA, Miyata H, Nunomura K, Lin B, Tani A, Kumanogoh A, Ikawa M, Wing JB, Standley DM, Takagi J, Suzuki K.
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
Sci Immunol 8(81):eadc9324, 2023.
https://doi.org/10.1126/sciimmunol.adc9324
Obara K, Kaneshige M, Suzuki M, Yokoyama O, Tazoe T, Nishimura Y.
Corticospinal interface to restore voluntary control of joint torque in a paralyzed forearm following spinal cord injury in non-human primates.
Front Neurosci 17:1127095, 2023.
https://doi.org/10.3389/fnins.2023.1127095
Liang J, Inoue A, Ikuta T, Xia R, Wang N, Kawakami K, Xu Z, Qian Y, Zhu X, Zhang A, Guo C, Huang Z, He Y.
Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation.
Nat Commun 14(1):1012, 2023.
https://doi.org/10.1038/s41467-023-36575-0
Cheng Y, Manabe I, Hayakawa S, Endo Y, Oishi Y.
Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages.
Front Immunol 14:1009973, 2023.
https://doi.org/10.3389/fimmu.2023.1009973
Ohue-Kitano R, Nonaka H, Nishida A, Masujima Y, Takahashi D, Ikeda T, Uwamizu A, Tanaka M, Kohjima M, Igarashi M, Katoh H, Tanaka T, Inoue A, Suganami T, Hase K, Ogawa Y, Aoki J, Kimura I.
Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84.
JCI Insight 8(2):e165469, 2023.
https://doi.org/10.1172/jci.insight.165469
Miyamoto J, Shimizu H, Hisa K, Matsuzaki C, Inuki S, Ando Y, Nishida A, Izumi A, Yamano M, Ushiroda C, Irie J, Katayama T, Ohno H, Itoh H, Yamamoto K, Kimura I.
Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides.
Gut Microbes 15(1):2161271, 2023.
https://doi.org/10.1080/19490976.2022.2161271
Ono Y, Kawakami K, Nakamura G, Ishida S, Aoki J, Inoue A.
Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs.
Commun Biol 6(1):112, 2023.
https://doi.org/10.1038/s42003-023-04465-2
Xu J, Wang Q, Hubner H, Hu Y, Niu X, Wang H, Maeda S, Inoue A, Tao Y, Gmeiner P, Du Y, Jin C, Kobilka BK.
Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nat Commun 14(1):376, 2023.
https://doi.org/10.1038/s41467-022-35726-z
Tatsumi M, Kishi T, Ishida S, Kawana H, Uwamizu A, Ono Y, Kawakami K, Aoki J, Inoue A.
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.
PLoS One 18(1):e0280448, 2023.
https://doi.org/10.1371/journal.pone.0280448
Niizawa T, Sakuraba R, Kusaka T, Kurihara Y, Sugashi T, Kawaguchi H, Kanno I, Masamoto K.
Spatiotemporal analysis of blood plasma and blood cell flow fluctuations of cerebral microcirculation in anesthetized rats.
J Cereb Blood Flow Metab 43(1):138-152, 2023.
https://doi.org/10.1177/0271678X221125743

2022

原著論文

Hara K, Murakami M, Niitsu Y, Takeuchi A, Horino M, Shiba K, Tsujimoto K, Komiya C, Ikeda K, Tsuiki M, Tanabe A, Tanaka T, Yokoyama M, Fujii Y, Naruse M, Yamada T.
Heterogeneous circulating miRNA profiles of PBMAH.
Front Endocrinol (Lausanne) 13:1073328, 2022.
https://doi.org/10.3389/fendo.2022.1073328
Nakamura Y, Yahiro T, Fukushima A, Kataoka N, Hioki H, Nakamura K.
Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling.
Sci Adv 8(51):eadd5463, 2022.
https://doi.org/10.1126/sciadv.add5463
Kaneshige M, Obara K, Suzuki M, Tazoe T, Nishimura Y.
Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys.
Elife 11:e78346, 2022.
https://doi.org/10.7554/eLife.78346
Umeda T, Isa T, Nishimura Y.
Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement.
Proc Natl Acad Sci U S A 119(48):e2208353119, 2022.
https://doi.org/10.1073/pnas.2208353119
Nawaz A, Bilal M, Fujisaka S, Kado T, Aslam MR, Ahmed S, Okabe K, Igarashi Y, Watanabe Y, Kuwano T, Tsuneyama K, Nishimura A, Nishida Y, Yamamoto S, Sasahara M, Imura J, Mori H, Matzuk MM, Kudo F, Manabe I, Uezumi A, Nakagawa T, Oishi Y, Tobe K.
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration.
Nat Commun 13(1):7058, 2022.
https://doi.org/10.1038/s41467-022-34191-y
Hayakawa S, Tamura A, Nikiforov N, Koike H, Kudo F, Cheng Y, Miyazaki T, Kubekina M, Kirichenko TV, Orekhov AN, Yui N, Manabe I, Oishi Y.
Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling.
JCI Insight 7(22):e138539, 2022.
https://doi.org/10.1172/jci.insight.138539
Janetzko J, Kise R, Barsi-Rhyne B, Siepe DH, Heydenreich FM, Kawakami K, Masureel M, Maeda S, Garcia KC, von Zastrow M, Inoue A, Kobilka BK.
Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.
Cell 185(24):4560-4573.e19, 2022.
https://doi.org/10.1016/j.cell.2022.10.018
Kubo H, Sawada S, Satoh M, Asai Y, Kodama S, Sato T, Tomiyama S, Seike J, Takahashi K, Kaneko K, Imai J, Katagiri H.
Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study.
Sci Rep 12(1):20130, 2022.
https://doi.org/10.1038/s41598-022-23521-1
Kohata M, Imai J, Izumi T, Yamamoto J, Kawana Y, Endo A, Sugawara H, Seike J, Kubo H, Komamura H, Sato T, Hosaka S, Munakata Y, Asai Y, Kodama S, Takahashi K, Kaneko K, Katagiri H.
Roles of FoxM1-driven basal β-cell proliferation in maintenance of β-cell mass and glucose tolerance during adulthood.
J Diabetes Investig 13(10):1666-1676, 2022.
https://doi.org/10.1111/jdi.13846
Usuda N, Sugawara SK, Fukuyama H, Nakazawa K, Amemiya K, Nishimura Y.
Quantitative comparison of corticospinal tracts arising from different cortical areas in humans.
Neurosci Res 183:30-49, 2022.
https://doi.org/10.1016/j.neures.2022.06.008
Suno R, Sugita Y, Morimoto K, Takazaki H, Tsujimoto H, Hirose M, Suno-Ikeda C, Nomura N, Hino T, Inoue A, Iwasaki K, Kato T, Iwata S, Kobayashi T.
Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex.
Cell Rep 40(11):111323, 2022.
https://doi.org/10.1016/j.celrep.2022.111323
Walker AR, Larsen CB, Kundu S, Stavrinidis C, Kim SH, Inoue A, Woodward DF, Lee YS, Migale R, MacIntyre DA, Terzidou V, Fanelli F, Khanjani S, Bennett PR, Hanyaloglu AC.
Functional rewiring of G protein-coupled receptor signaling in human labor.
Cell Rep 40(10):111318, 2022.
https://doi.org/10.1016/j.celrep.2022.111318
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O.
Endogenous ligand recognition and structural transition of a human PTH receptor.
Mol Cell 82(18):3468-3483.e5, 2022.
https://doi.org/10.1016/j.molcel.2022.07.003
Fukushima A, Kataoka N, Nakamura K.
An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflows.
Cell Rep 40(12):111380, 2022.
https://doi.org/10.1016/j.celrep.2022.111380
Kawai K, Tazoe T, Yanai T, Kanosue K, Nishimura Y.
Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation.
Front Hum Neurosci 16:1016064, 2022.
https://doi.org/10.3389/fnhum.2022.1016064
Suzuki M, Nishimura Y.
The ventral striatum contributes to the activity of the motor cortex and motor outputs in monkeys.
Front Syst Neurosci 16:979272, 2022.
https://doi.org/10.3389/fnsys.2022.979272
Koba S, Kumada N, Narai E, Kataoka N, Nakamura K, Watanabe T.
A brainstem circuit coordinating locomotor activities and sympathetic cardiovascular responses.
Nat Commun 13(1):5079, 2022.
https://doi.org/10.1038/s41467-022-32823-x
Baidya M, Chaturvedi M, Dwivedi-Agnihotri H, Ranjan A, Devost D, Namkung Y, Stepniewski TM, Pandey S, Baruah M, Panigrahi B, Sarma P, Yadav MK, Maharana J, Banerjee R, Kawakami K, Inoue A, Selent J, Laporte SA, Hebert TE, Shukla AK.
Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody.
Nat Commun 13(1):4634, 2022.
https://doi.org/10.1038/s41467-022-32386-x
Heo Y, Ishimoto N, Jeon YE, Yun JH, Ohki M, Anraku Y, Sasaki M, Kita S, Fukuhara H, Ikuta T, Kawakami K, Inoue A, Maenaka K, Tame JRH, Lee W, Park SY.
Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.
PLoS Biol 20(8):e3001714, 2022.
https://doi.org/10.1371/journal.pbio.3001714
Nakayama Y, Sugawara SK, Fukunaga M, Hamano YH, Sadato N, Nishimura Y.
The dorsal premotor cortex encodes the step-by-step planning processes for goal-directed motor behavior in humans.
Neuroimage 256:119221, 2022.
https://doi.org/10.1016/j.neuroimage.2022.119221
Ikegame S,Yoshimoto M, Miki K.
Simultaneous measurement of central amygdala neuronal activity and sympathetic nerve activity during daily activities in rats.
Exp Physiol 107(9):1071-1080, 2022.
https://doi.org/10.1113/EP090538
Dixon AD, Inoue A, Robson SA, Culhane KJ, Trinidad JC, Sivaramakrishnan S, Bumbak F, Ziarek JJ.
Effect of Ligands and Transducers on the Neurotensin Receptor 1 Conformational Ensemble.
J Am Chem Soc 144(23):10241-10250, 2022.
https://doi.org/10.1021/jacs.2c00828
Nureki I, Kobayashi K, Tanaka T, Demura K, Inoue A, Shihoya W, Nureki O.
Cryo-EM structures of the β3 adrenergic receptor bound to solabegron and isoproterenol.
Biochem Biophys Res Commun 611:158-164, 2022.
https://doi.org/10.1016/j.bbrc.2022.04.065
Matic M, Singh G, Carli F, Oliveira Rosa N, Miglionico P, Magni L, Gutkind JS, Russell RB, Inoue A, Raimondi F.
PRECOGx: exploring GPCR signaling mechanisms with deep protein representations.
Nucleic Acids Res 50(W1):W598-W610, 2022.
https://doi.org/10.1093/nar/gkac426
El Khamlichi C, Reverchon F, Hervouet-Coste N, Robin E, Chopin N, Deau E, Madouri F, Guimpied C, Colas C, Menuet A, Inoue A, Bojarski AJ, Guillaumet G, Suzenet F, Reiter E, Morisset-Lopez S.
Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors.
Proc Natl Acad Sci U S A 119(21):e2118847119, 2022.
https://doi.org/10.1073/pnas.2118847119
Ninomiya T, Nakagawa H, Inoue KI, Nishimura Y, Oishi T, Yamashita T, Takada M.
Origin of Multisynaptic Corticospinal Pathway to Forelimb Segments in Macaques and Its Reorganization After Spinal Cord Injury.
Front Neural Circuits 16:847100, 2022.
https://doi.org/10.3389/fncir.2022.847100
Miki K, Ikegame S, Yoshimoto M.
Regional differences in sympathetic nerve activity are generated by multiple arterial baroreflex loops arranged in parallel.
Front Physiol 13:858654, 2022.
https://doi.org/10.3389/fphys.2022.858654
Nonaka H, Ohue-Kitano R, Masujima Y, Igarashi M, Kimura I.
Dietary medium-chain triglyceride decanoate affects glucose homeostasis through GPR84-mediated GLP-1 secretion in mice.
Front Nutr 9:e848450, 2022.
https://doi.org/10.3389/fnut.2022.848450
Yakubo K, Fujiki Y.
A general model of hierarchical fractal scale-free networks.
PLoS One 17(3):e0264589, 2022.
https://doi.org/10.1371/journal.pone.0264589
Zheng K, Smith JS, Eiger DS, Warman A, Choi I, Honeycutt CC, Boldizsar N, Gundry JN, Pack TF, Inoue A, Caron MG, Rajagopal S.
Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes.
Sci Signal 15(726):eabg5203, 2022.
https://doi.org/10.1126/scisignal.abg5203
Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y.
Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism.
Nat Chem Biol 18(3):281-288, 2022.
https://doi.org/10.1038/s41589-021-00930-3
Yuzawa R, Koike H, Manabe I, Oishi Y.
VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes.
Sci Rep 12(1):1377, 2022.
https://doi.org/10.1038/s41598-022-05354-0
Yasugahira Y, Nagayama M.
On a numerical bifurcation analysis of a particle reaction‐diffusion model for a motion of two self‐propelled disks.
Jpn J Ind Appl Math 39:631-652, 2022.
https://doi.org/10.1007/s13160-021-00498-4
Kawakami K, Yanagawa M, Hiratsuka S, Yoshida M, Ono Y, Hiroshima M, Ueda M, Aoki J, Sako Y, Inoue A.
Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias.
Nat Commun 13(1):487, 2022.
https://doi.org/10.1038/s41467-022-28056-7
Iio K, Kutsumura N, Nagumo Y, Saitoh T, Tokuda A, Hashimoto K, Yamamoto N, Kise R, Inoue A, Mizoguchi H, Nagase H.
Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.
Bioorg Med Chem Lett 56:128485, 2022.
https://doi.org/10.1016/j.bmcl.2021.128485

総説

Ikeda T, Nishida A, Yamano M, Kimura I.
Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases.
Pharmacol Ther 239:108273, 2022.
https://doi.org/10.1016/j.pharmthera.2022.108273
Horino M, Ikeda K, Yamada T.
The Role of Thermogenic Fat Tissue in Energy Consumption.
Curr Issues Mol Biol 44(7):3166-3179, 2022.
https://doi.org/10.3390/cimb44070219
Morrison SF, Nakamura K, Tupone D.
Thermoregulation in mice: The road to understanding torpor hypothermia and the shortcomings of a circuit for generating fever.
Temperature (Austin) 9(1):8-11, 2022.
https://doi.org/10.1080/23328940.2021.2021059
Imai J, Katagiri H.
Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation.
Int Immunol 34(2):67-79, 2022.
https://doi.org/10.1093/intimm/dxab023
Nakamura K, Morrison SF.
Central sympathetic network for thermoregulatory responses to psychological stress.
Auton Neurosci 237:102918, 2022.
https://doi.org/10.1016/j.autneu.2021.102918
Nakamura K, Nakamura Y, Kataoka N.
A hypothalamomedullary network for physiological responses to environmental stresses.
Nat Rev Neurosci 23(1):35-52, 2022.
https://doi.org/10.1038/s41583-021-00532-x
Fujiu K, Manabe I.
Nerve-macrophage interactions in cardiovascular disease.
Int Immunol 34(2):81-95, 2022.
https://doi.org/10.1093/intimm/dxab036

2021

原著論文

Kume S.
Ketone bodies: back to a place in the sun.
Kidney Int 100(5):976-978, 2021.
https://doi.org/10.1016/j.kint.2021.07.022
Pandey S, Kumari P, Baidya M, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li XX, Cui CS, Lee JD, Kawakami K, Chaturvedi M, Ranjan A, Laporte SA, Woodruff TM, Inoue A, Shukla AK.
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.
Mol Cell 81(18):1-17, 2021.
https://doi.org/10.1016/j.molcel.2021.09.007
Liu L, Koike H, Ono T, Hayashi S, Kudo F, Kaneda A, Kagechika H, Manabe I, Nakashima T, Oishi Y.
Identification of a novel KLF5-dependent program and drug development for skeletal muscle atrophy.
Proc Natl Acad Sci U S A 118(35):e2102895118, 2021.
https://doi.org/10.1073/pnas.2102895118
Watanabe K, Yamano M, Masujima Y, Ohue-Kitano R, Kimura I.
Curdlan intake changes gut microbial composition, short-chain fatty acid production, and bile acid transformation in mice.
Biochem Biophys Rep 27:101095, 2021.
https://doi.org/10.1016/j.bbrep.2021.101095
McGlone ER, Manchanda Y, Jones B, Pickford P, Inoue A, Carling D, Bloom SR, Tan T, Tomas A.
Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.
Mol Metab 53:101296, 2021.
https://doi.org/10.1016/j.molmet.2021.101296
Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M, Crown SB, Osawa T, Sakai J, McGarrah RW, White PJ, Nakamura K, Kajimura S.
Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever.
Elife 10:e66865, 2021.
https://doi.org/10.7554/eLife.66865
Chiba H.
A Hopf bifurcation in the Kuramoto-Daido model.
J Diff Equ 280:545-570, 2021.
https://doi.org/10.1016/j.jde.2021.01.024
Kubota SI, Takahashi K, Mano T, Matsumoto K, Katsumata T, Shi S, Tainaka K, Ueda HR, Ehata S, Miyazono K.
Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing.
Commun Biol 4(1):294, 2021.
https://doi.org/10.1038/s42003-021-01786-y
Iwama T, Kano K, Saigusa D, Ekroos K, van Echten-Deckert G, Vogt J, Aoki J.
Development of an On-Tissue Derivatization Method for MALDI Mass Spectrometry Imaging of Bioactive Lipids Containing Phosphate Monoester Using Phos-tag.
Anal Chem 93(8):3867-3875, 2021.
https://doi.org/10.1021/acs.analchem.0c04479
Adachi Y, Ota K, Minami I, Yamada T, Watanabe T.
Lower Insulin Secretion Is Associated with Hippocampal and Parahippocampal Gyrus Atrophy in Elderly Patients with Type 2 Diabetes Mellitus.
J Diabetes Investig 12(10):1908-1913, 2021.
https://doi.org/10.1111/jdi.13554
Nakamaru R, Yamamoto K, Akasaka H, Rakugi H, Kurihara I, Yoneda T, Ichijo T, Katabami T, Tsuiki M, Wada N, Yamada T, Kobayashi H, Tamura K, Ogawa Y, Kawashima J, Inagaki N, Fujita M, Watanabe M, Kamemura K, Okamura S, Tanabe A, Naruse M; JPAS/JRAS Study Group.
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総説

Richardson DS, Guan W, Matsumoto K, Pan C, Chung K, Erturk A, Ueda HR, Lichtman JW.
Tissue clearing.
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Control of immune cell trafficking through inter-organ communication.
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2020

原著論文

Kawahori K, Kondo Y, Yuan X, Kawasaki Y, Hanzawa N, Tsujimoto K, Wada F, Kohda T, Ishigami A, Yamada T, Ogawa Y, Hashimoto K.
Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver.
Sci Rep 10(1):21228, 2020.
https://doi.org/10.1038/s41598-020-77962-7