研究成果

2025 | 2024 | 2023 | 2022 | 2021 | 2020

2025

原著論文

Kubo H, Imai J, Izumi T, Kohata M, Kawana Y, Endo A, Sugawara H, Seike J, Horiuchi T, Komamura H, Sato T, Hosaka S, Asai Y, Kodama S, Takahashi K, Kaneko K, Katagiri H.
Colonic inflammation triggers β cell proliferation during obesity development via a liver-to-pancreas interorgan mechanism.
JCI Insight 10(9):e183864, 2025.
https://doi.org/10.1172/jci.insight.183864
Uwamizu A, Shinjo Y, Tatstumi M, Kano K, Makide K, Kitamura H, Satoh K, Fukami F, Kawano T, Miyasaka T, Takahashi T, Nakajima O, Ohwada T, Inoue A, Omi J, Aoki J.
Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation.
iScience 28:112420, 2025.
https://doi.org/10.1016/j.isci.2025.112420
Hasumi E, Fujiu K, Chen Y, Miyamoto S, Oida M, Shimizu Y, Kani K, Goto K, Uchida R, Liu Y, Oshima T, Matsuda J, Matsubara TJ, Sugita J, Nakayama Y, Oguri G, Kojima T, Maru Y, Kodera S, Akazawa H, Shoda M, Komuro I.
Heart failure monitoring with a single-lead electrocardiogram at home.
Int J Cardiol 432:133203, 2025.
https://doi.org/10.1016/j.ijcard.2025.133203
Masamoto K.
Optical Imaging of Microvascular Function in the Brain.
IEEE Journal of Selected Topics in Quantum Electronics 31(4):1-10, 2025.
https://doi.org/10.1109/JSTQE.2025.3550356
Kugawa M, Kawakami K, Kise R, Suomivuori CM, Tsujimura M, Kobayashi K, Kojima A, Inoue WJ, Fukuda M, Matsui TE, Fukunaga A, Koyanagi J, Kim S, Ikeda H, Yamashita K, Saito K, Ishikita H, Dror RO, Inoue A, Kato HE.
Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2.
Nat Commun 16(1):2809, 2025.
https://doi.org/10.1038/s41467-025-57983-4
Roy SM, Acquarone E, Argyrousi EK, Zhang H, Staniszewski A, Inoue A, Ziarek JJ, Arancio O, Watterson DM.
Optimized 5-HT2b inhibitors for neuropsychiatric syndromes with cognitive dysfunction.
Alzheimers Dement (N Y) 11(1):e70073, 2025.
https://doi.org/10.1002/trc2.70073
Kajino K, Sugai T, Kakumoto T, Kise R, Suzuki R, Tokuda A, Sekiya Y, Katamoto R, Kutsumura N, Nagumo Y, Hirokawa T, Inoue A, Saitoh T.
Structure-Signal Relationships of the δ-Opioid-Receptor (DOR)-Selective Agonist KNT-127-Part II: Quinoline Ring Modifications for Enhanced G-Protein Signaling and Reduced β-Arrestin Recruitment.
Chem Pharm Bull (Tokyo) 73(4):336-348, 2025.
https://doi.org/10.1248/cpb.c24-00796
Kajino K, Sugai T, Kise R, Suzuki R, Tokuda A, Sekiya Y, Kakumoto T, Katamoto R, Kutsumura N, Nagumo Y, Inoue A, Saitoh T.
Structure-Signal Relationships of the δ-Opioid-Receptor (DOR)-Selective Agonist KNT-127-Part I: Impact of the Morphinan Skeleton on the G-Protein-Biased DOR Agonism.
Chem Pharm Bull (Tokyo) 73(3):246-256, 2025.
https://doi.org/10.1248/cpb.c25-00012
Hirabayashi S, Uyeda A, Manabe I, Yonezu Y, Saito T, Saido TC, Misawa H, Ogasawara Y, Kinoshita K, Muramatsu R.
CCN1 derived from vascular endothelial cells impairs cognitive function in Alzheimer's disease model mice.
J Pharmacol Sci 157(3):146-155, 2025.
https://doi.org/10.1016/j.jphs.2025.01.004
Yoshimoto M, Yagi K, Ikegame S, Miki K.
Progressive Increase in Renal Sympathetic Nerve Activity Induced by Cold Exposure.
Hypertension 82(4):615-623, 2025.
https://doi.org/10.1161/HYPERTENSIONAHA.124.23499
Watanabe K, Yamano M, Miyamoto J, Ohue-Kitano R, Masujima Y, Sasahara D, Mouri Y, Kono N, Inuki S , Osakada F, Nagaoka K, Aoki J, Sugiura Y, Ohno H, Kondoh E, Kimura I.
Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state.
Cell Rep 44(3):115433, 2025.
https://doi.org/10.1016/j.celrep.2025.115433
Miki K, Miyaura W, Ikegame S, Yoshimoto M.
Method for measuring cervical vagal nerve activity in conscious rats.
Am J Physiol Endocrinol Metab 328(2):E230-E241, 2025.
https://doi.org/10.1152/ajpendo.00184.2024
Arai K, Ono Y, Hirai N, Sugiura Y, Kaneko K, Matsuda S, Iio K, Kajino K, Saitoh T, Wei FY, Katagiri H, Inoue A.
Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity.
Biochim Biophys Acta Mol Basis Dis 1871(2):167566, 2025.
https://doi.org/10.1016/j.bbadis.2024.167566
Jack CE, Cope EM, Lemel L, Canals M, Drube J, Hoffmann C, Inoue A, Hislop JN, Thompson D.
GRK5 regulates endocytosis of FPR2 independent of β-Arrestins.
J Biol Chem 301(2):108112, 2025.
https://doi.org/10.1016/j.jbc.2024.108112
Nishimura A, Nishiyama K, Ito T, Mi X, Kato Y, Inoue A, Aoki J, Nishida M.
Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate.
Cells 14(3):216, 2025.
https://doi.org/10.3390/cells14030216
Hahn H, Daly C, Little J 4th, Perry-Hauser NA, Flores-Espinoza E, Inoue A, Plouffe B, Thomsen ARB.
Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration.
Elife 13:RP99373, 2025.
https://doi.org/10.7554/eLife.99373
Quan L, Uyeda A, Manabe I, Muramatsu R.
Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury.
J Neuroinflammation 22(1):28, 2025.
https://doi.org/10.1186/s12974-025-03351-4
Moo EV, Moller TC, Sorensen FA, Inoue A, Brauner-Osborne H.
Arrestin-independent internalization of the GLP-1 receptor is facilitated by a GRK, clathrin, and caveolae-dependent mechanism.
FEBS J 292(7):1675-1695, 2025.
https://doi.org/10.1111/febs.17338
Li J, Inoue A, Manglik A, von Zastrow M.
Role of the G protein-coupled receptor kinase 2/3 N terminus in discriminating the endocytic effects of opioid agonist drugs.
Mol Pharmacol 107(1):100003, 2025.
https://doi.org/10.1124/molpharm.124.000951
Zhou Y, Rashad S, Ando D, Kobayashi Y, Tominaga T, Niizuma K.
Dynamic mRNA Stability Buffer Transcriptional Activation During Neuronal Differentiation and Is Regulated by SAMD4A.
J Cell Physiol 240(1):e31477, 2025.
https://doi.org/10.1002/jcp.31477
Ando D, Rashad S, Begley TJ, Endo H, Aoki M, Dedon PC, Niizuma K.
Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation.
Int J Mol Sci 26(2):706, 2025.
https://doi.org/10.3390/ijms26020706
Matsumoto K, Harada SY, Yoshida SY, Narumi R, Mitani TT, Yada S, Sato A, Morii E, Shimizu Y, Ueda HR.
DECODE enables high-throughput mapping of antibody epitopes at single amino acid resolution.
PLoS Biol 23(1):e3002707, 2025.
https://doi.org/10.1371/journal.pbio.3002707
Carino CMC, Hiratsuka S, Kise R, Nakamura G, Kawakami K, Yanagawa M, Inoue A.
Signal profiles and spatial regulation of β-arrestin recruitment through Gβ5 and GRK3 at the μ-opioid receptor.
Eur J Pharmacol 987:177151, 2025.
https://doi.org/10.1016/j.ejphar.2024.177151
Shimizu H, Miyamoto J, Hisa K, Ohue-Kitano R, Takada H, Yamano M, Nishida A, Sasahara D, Masujima Y, Watanabe K, Nishikawa S, Takahashi S, Ikeda T, Nakajima Y, Yoshida N, Matsuzaki C, Kageyama T, Hayashi I, Matsuki A, Akashi R, Kitahama S, Ueyama M, Murakami T, Inuki S, Irie J, Satoh-Asahara N, Toju H, Mori H, Nakaoka S, Yamashita T, Toyoda A, Yamamoto K, Ohno H, Katayama T, Itoh H, Kimura I.
Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides.
Nat Commun 16(1):1145, 2025.
https://doi.org/10.1038/s41467-025-56470-0
Akiyama F, Matsumoto K, Yamashita K, Oishi A, Kitaoka T, Ueda HR.
A multiwell plate approach to increase the sample throughput during tissue clearing.
Nat Protoc 20(4):967-988, 2025.
https://doi.org/10.1038/s41596-024-01080-1

2024

原著論文

Ikuta T, Suzuki R, Inoue A.
The repertoire of G-protein-coupled receptor variations in the Japanese population 54KJPN.
Genes Cells 29(11):1026-1036, 2024.
https://doi.org/10.1111/gtc.13164
De Pascali F, Inoue A, Benovic JL.
Diverse pathways in GPCR-mediated activation of Ca2+ mobilization in HEK293 cells.
J Biol Chem 300(11):107882, 2024.
https://doi.org/10.1016/j.jbc.2024.107882
Pittala S, Haspula D, Cui Y, Yang WM, Kim YB, Davis RJ, Wing A, Rotman Y, McGuinness OP, Inoue A, Wess J.
G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis.
Nat Commun 15(1):9996, 2024.
https://doi.org/10.1038/s41467-024-54299-7
Suzuki H, Murata J, Unekawa M, Kanno I, Izawa Y, Tomita Y, Tanaka KF, Nakahara J, Masamoto K.
Microfluctuations in Capillary Lumens Independent of Pericyte Lining Density in the Anesthetized Mouse Cortex.
Microcirculation 31(8):e12885, 2024.
https://doi.org/10.1111/micc.12885
Tanabe H, Sato M, Miyake A, Shimajiri Y, Ojima T, Narita A, Saito H, Tanaka K, Masuzaki H, Kazama JJ, Katagiri H, Tamiya G, Kawakami E, Shimabukuro M.
Machine learning-based reproducible prediction of type 2 diabetes subtypes.
Diabetologia 67(11):2446-2458, 2024.
https://doi.org/10.1007/s00125-024-06248-8
Nishida A, Ohue-Kitano R, Masujima Y, Nonaka H, Igarashi M, Ikeda T, Kimura I.
Medium-chain fatty acid receptor GPR84 deficiency leads to metabolic homeostasis dysfunction in mice fed high-fat diet.
FASEB Bioadv 6(11):526-538, 2024.
https://doi.org/10.1096/fba.2024-00075
Yamada RG, Matsuzawa K, Ode KL, Ueda HR.
An automated sleep staging tool based on simple statistical features of mice electroencephalography (EEG) and electromyography (EMG) data.
Eur J Neurosci 60(7):5467-5486, 2024.
https://doi.org/10.1111/ejn.16465
Yoda T, Sako Y, Inoue A, Yanagawa M.
Four-color single-molecule imaging system for tracking GPCR dynamics with fluorescent HiBiT peptide.
Biophys Physicobiol 21(3):e210020, 2024.
https://doi.org/10.2142/biophysico.bppb-v21.0020
Uchida R, Hasumi E, Chen Y, Oida M, Goto K, Kani K, Oshima T, Matsubara TJ, Shimizu Y, Oguri G, Kojima T, Sugita J, Nakayama Y, Yamamichi N, Komuro I, Fujiu K.
Detection of hypertension using a target spectral camera: a prospective clinical study.
Sci Rep 14(1):21882, 2024.
https://doi.org/10.1038/s41598-024-70903-8
Takayama J, Makino S, Funayama T, Ueki M, Narita A, Murakami K, Orui M, Ishikuro M, Obara T, the Tohoku Medical Megabank Project Study Group, Kuriyama S, Yamamoto M, Tamiya G.
A fine-scale genetic map of the Japanese population.
Clin Genet 106(3):284-292, 2024.
https://doi.org/10.1111/cge.14536
Sirbu A, Bathe-Peters M, Kumar JLM, Inoue A, Lohse MJ, Annibale P.
Cell swelling enhances ligand-driven β-adrenergic signaling.
Nat Commun 15(1):7822, 2024.
https://doi.org/10.1038/s41467-024-52191-y
Brands J, Bravo S, Jurgenliemke L, Gratz L, Schihada H, Frechen F, Alenfelder J, Pfeil C, Ohse PG, Hiratsuka S, Kawakami K, Schmacke LC, Heycke N, Inoue A, Konig G, Pfeifer A, Wachten D, Schulte G, Steinmetzer T, Watts VJ, Gomeza J, Simon K, Kostenis E.
A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors.
Nat Commun 15(1):7684, 2024.
https://doi.org/10.1038/s41467-024-51991-6
Yin H, Kamakura N, Qian Y, Tatsumi M, Ikuta T, Liang J, Xu Z, Xia R, Zhang A, Guo C, Inoue A, He Y.
Insights into lysophosphatidylserine recognition and Gα12/13-coupling specificity of P2Y10.
Cell Chem Biol S2451-9456(24):00353-2, 2024.
https://doi.org/10.1016/j.chembiol.2024.08.005
Saha S, Khanppnavar B, Maharana J, Kim H, Carino CMC, Daly C, Houston S, Sharma S, Zaidi N, Dalal A, Mishra S, Ganguly M, Tiwari D, Kumari P, Jhingan GD, Yadav PN, Plouffe B, Inoue A, Chung KY, Banerjee R, Korkhov VM, Shukla AK.
Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor.
Cell 187(17):4751-4769, 2024.
https://doi.org/10.1016/j.cell.2024.07.005
Pauza AG, Thakkar P, Shen X, Felippe I, Rosmann K, Oya M, Nakamura K, Broichhagen J, Hodson DJ, Pauza DH, Murphy D, Paton JFR
Melanocortin system activates carotid body arterial chemoreceptors in hypertension.
BioRxiv 2024.
https://doi.org/10.1101/2024.07.22.604704
Manchanda Y, ElEid L, Oqua AI, Ramchunder Z, Choi J, Shchepinova MM, Rutter GA, Inoue A, Tate EW, Jones B, Tomas A.
Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling.
Sci Signal 17(843):eabq7038, 2024.
https://doi.org/10.1126/scisignal.abq7038
Iwama T, Kano K, Kawana H, Shindou H, Shimizu T, Kono N, Aoki J.
Visualization of Phospholipid Synthesis on Tissue Sections Using Functional Mass Spectrometry Imaging.
Anal Chem 96(29):11771-11779, 2024.
https://doi.org/10.1021/acs.analchem.4c01219
Ham D, Shihoya W, Nureki O, Inoue A, Chung KY.
Molecular mechanism of the endothelin receptor type B interactions with Gs, Gi, and Gq.
Structure 32(10):1632-1639, 2024.
https://doi.org/10.1016/j.str.2024.06.020
Kawana Y, Imai J, Morizawa YM, Ikoma Y, Kohata M, Komamura H, Sato T, Izumi T, Yamamoto J, Endo A, Sugawara H, Kubo H, Hosaka S, Munakata Y, Asai Y, Kodama S, Takahashi K, Kaneko K, Sawada S, Yamada T, Ito A, Niizuma K, Tominaga T, Yamanaka A, Matsui K, Katagiri H.
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation.
Nat Biomed Eng 8(7):808-822, 2024.
https://doi.org/10.1038/s41551-023-01113-2
Toth AD, Szalai B, Kovacs OT, Garger D, Prokop S, Soltesz-Katona E, Balla A, Inoue A, Varnai P, Turu G, Hunyady L.
G protein-coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling.
Sci Signal 17(842):eadi0934, 2024.
https://doi.org/10.1126/scisignal.adi0934
Iwama A, Kise R, Akasaka H, Sano FK, Oshima HS, Inoue A, Shihoya W, Nureki O.
Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103.
Nat Commun 15(1):4769, 2024.
https://doi.org/10.1038/s41467-024-49030-5
Saito A, Kise R, Inoue A.
Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling.
Pharm Rev 76(4):599-619, 2024.
https://doi.org/10.1124/pharmrev.124.001186
Junyong E, Ueda Y, Utsumi S, Gao Y, Suito H, Kume S, Katagiri H, Nagayama M.
Parameter estimation and analysis of 9-compartment mathematical model for glucose-insulin dynamics.
Proceedings of the Conference on Computational Engineering and Science 29(1):1-5, 2024.
Otomo K, Omura T, Nozawa Y, Edwards SJ, Sato Y, Saito Y, Yagishita S, Uchida H, Watakabe Y, Naitou K, Yanai R, Sahara N, Takagi S, Katayama R, Iwata Y, Shiokawa T, Hayakawa Y, Otsuka K, Watanabe-Takano H, Haneda Y, Fukuhara S, Fujiwara M, Nii T, Meno C, Takeshita N, Yashiro K, Rosales Rocabado JM, Kaku M, Yamada T, Oishi Y, Koike H, Cheng Y, Sekine K, Koga J-i, Sugiyama K, Kimura K, Karube F, Kim H, Manabe I, Nemoto T, Tainaka K, Hamada A, Brismar H, Susaki EA.
descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques.
Nat Commun 15(1):4941, 2024.
https://doi.org/10.1038/s41467-024-49131-1
Miyamoto J, Ando Y, Nishida A, Yamano M, Suzuki S, Takada H, Kimura I.
Fructooligosaccharides intake during pregnancy improves metabolic phenotype of offspring in high fat diet-induced obese mice.
Mol Nutr Food Res 68(9):e2300758, 2024.
https://doi.org/10.1002/mnfr.202300758
Nakayama Y, Fujiu K, Oshima T, Matsuda J, Sugita J, Matsubara TJ, Liu Y, Goto K, Kani K, Uchida R, Takeda N, Morita H, Xiao Y, Hayashi M, Maru Y, Hasumi E, Kojima T, Ishiguro S, Kijima Y, Yachie N, Yamazaki S, Yamamoto R, Kudo F, Nakanishi M, Iwama A, Fujiki R, Kaneda A, Ohara O, Nagai R, Manabe I, Komuro I.
Heart failure promotes multimorbidity through innate immune memory.
Sci Immunol 9(95):eade3814, 2024.
https://doi.org/10.1126/sciimmunol.ade3814
Sugawara SK, Nishimura Y.
The mesocortical system encodes the strength of subsequent force generation.
Neuroscience Insights 19:26331055241256900, 2024.
https://doi.org/10.1177/26331055241256948
Toth AD, Soltesz-Katona E, Kis K, Guti V, Gilzer S, Prokop S, Boros R, Misak A, Balla A, Varnai P, Turiak L, Acs A, Drahos L, Inoue A, Hunyady L, Turu G.
ArreSTick motif controls β-arrestin-binding stability and extends phosphorylation-dependent β-arrestin interactions to non-receptor proteins.
Cell Rep 43(5):114241, 2024.
https://doi.org/10.1016/j.celrep.2024.114241
Tatsumi M, Cruz C, Kamakura N, Kuwabara R, Nakamura G, Ikuta T, Abrol R, Inoue A.
Identification of Gα12-vs-Gα13-coupling determinants and development of a Gα12/13-coupled designer GPCR.
Sci Rep 14(1):11119, 2024.
https://doi.org/10.1038/s41598-024-61506-4
Kuramoto R, Kise R, Kanno M, Kawakami K, Ikuta T, Makita N, Inoue A.
Therapeutic potentials of nonpeptidic V2R agonists for partial cNDI-causing V2R mutants.
PLoS One 19(5):e0303507, 2024.
https://doi.org/10.1371/journal.pone.0303507
Hoshina M, Ojima S, Kawasaki A, Doi K, Ohta S, Inoue A, Murayama H.
Development and basic performance verification of a rapid homogeneous bioassay for agonistic antibodies against the thyroid-stimulating hormone receptor.
J Immunol Methods 528:113655, 2024.
https://doi.org/10.1016/j.jim.2024.113655
Oya M, Miyasaka Y, Nakamura Y, Tanaka M, Suganami T, Mashimo T, Nakamura K.
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia.
Cell Metab 36(5):1044-1058, 2024.
https://doi.org/10.1016/j.cmet.2024.02.010
McNeill SM, Lu J, Marion C Carino C, Inoue A, Zhao P, Sexton PM, Wootten D.
The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation.
Biochem Pharmacol 222:116119, 2024.
https://doi.org/10.1016/j.bcp.2024.116119
Zecchin D, Knopfel N, Gluck AK, Stevenson M, Sauvadet A, Polubothu S, Barberan-Martin S, Michailidis F, Bryant D, Inoue A, Lines KE, Hannan FM, Semple RK, Thakker RV, Kinsler VA.
GNAQ/GNA11 Mosaicism Causes Aberrant Calcium Signaling Susceptible to Targeted Therapeutics.
J Invest Dermatol 144(4):811-819, 2024.
https://doi.org/10.1016/j.jid.2023.08.028
Kise R, Inoue A.
GPCR signaling bias: an emerging framework for opioid drug development.
J Biochem 175(4):367-376, 2024.
https://doi.org/10.1093/jb/mvae013
Ham D, Inoue A, Xu J, Du Y, Chung KY.
Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq.
Commun Biol 7(1):362, 2024.
https://doi.org/10.1038/s42003-024-06056-1
Chen G, Staffen N, Wu Z, Xu X, Pan J, Inoue A, Shi T, Gmeiner P, Du Y, Xu J.
Structural and functional characterization of the endogenous agonist for orphan receptor GPR3.
Cell Res 34(3):262-265, 2024.
https://doi.org/10.1038/s41422-023-00919-8
Imamura K, Akagi KI, Miyanoiri Y, Tsujimoto H, Hirokawa T, Ashida H, Murakami K, Inoue A, Suno R, Ikegami T, Sekiyama N, Iwata S, Kobayashi T, Tochio H.
Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy.
Structure 32(3):352-361, 2024.
https://doi.org/10.1016/j.str.2023.12.008
Omi J, Kato T, Yoshihama Y, Sawada K, Kono N, Aoki J.
Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma.
J Cell Biol 223(2):e202212074, 2024.
https://doi.org/10.1083/jcb.202212074
Onodera K, Hasegawa Y, Yokota N, Tamura S, Kinno H, Takahashi I, Chiba H, Kojima H, Katagiri H, Nata K, Ishigaki Y
A newly identified compound activating UCP1 inhibits obesity and its related metabolic disorders.
Obesity 32(2):324-338, 2024.
https://doi.org/10.1002/oby.23948
Jayakody T, Inoue A, Kannan S, Nakamura G, Kawakami K, Mendis K, Nguyen TB, Li J, Herr DR, Verma CS, Dawe GS.
Mechanisms of biased agonism by Gαi/o-biased stapled peptide agonists of the relaxin-3 receptor.
Sci Signal 17(823):eabl5880, 2024.
https://doi.org/10.1126/scisignal.abl5880
Kajitani N, Okada-Tsuchioka M, Inoue A, Miyano K, Masuda T, Boku S, Iwamoto K, Ohtsuki S, Uezono Y, Aoki J, Takebayashi M.
G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression.
Neuropsychopharmacology 49(3):561-572, 2024.
https://doi.org/10.1038/s41386-023-01727-9
Moller TC, Moo EV, Inoue A, Pedersen MF, Brauner-Osborne H.
Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins.
Biochim Biophys Acta Mol Cell Res 1871(1):119584, 2024.
https://doi.org/10.1016/j.bbamcr.2023.119584
Oishi Y, Koike H, Kumagami N, Nakagawa Y, Araki M, Taketomi Y, Miki Y, Matsuda S, Matsuzaka T, Ozawa H, Shimano H, Murakami M, Manabe I.
Macrophage SREBP1 regulates skeletal muscle regeneration.
Front Immunol 14:1251784, 2024.
https://doi.org/10.3389/fimmu.2023.1251784

総説

Mitani TT, Susaki EA, Matsumoto K, Ueda HR.
Realization of cellomics to dive into the whole-body or whole-organ cell cloud.
Nat methods 21(7):1138-1142, 2024.
https://doi.org/10.1038/s41592-024-02307-5
Shirai T, Nakai A, Suzuki K.
Chemoattractant receptor signaling in humoral immunity.
Int Immunol 36(9):429-438, 2024.
https://doi.org/10.1093/intimm/dxae021
Tsuruta H, Yamahara K, Yasuda-Yamahara M, Kume S.
Emerging pathophysiological roles of ketone bodies.
Physiology 39(3):167-177, 2024.
https://doi.org/10.1152/physiol.00031.2023
Yamahara K, Yasuda-Yamahara M, Kume S.
A novel therapeutic target for kidney diseases: Lessons learned from starvation response.
Pharmacol Therapeut 254:108590, 2024.
https://doi.org/10.1016/j.pharmthera.2024.108590
Yamahara K, Yasuda-Yamahara M, Kuwagata S, Chin-Kanasaki M, Kume S.
Ketone body metabolism in diabetic kidney disease.
Kidney360 5(2):320-326, 2024.
https://doi.org/10.34067/KID.0000000000000359

2023

原著論文

Abdelwahid MAS, Ohsawa K, Uwamizu A, Kano K, Aoki J, Doi T.
Synthesis and Biological Evaluation of Lysophosphatidic Acid Analogues Using Conformational Restriction and Bioisosteric Replacement Strategies.
ACS Omega 8(51):49278-49288, 2023.
https://doi.org/10.1021/acsomega.3c07668
Murakami M, Hara K, Ikeda K, Horino M, Okazaki R, Niitsu Y, Takeuchi A, Aoki J, Shiba K, Tsujimoto K, Komiya C, Nakamura Y, Kurata M, Akashi T, Fujii Y, Yamada T.
Single-Nuclei Analysis Reveals Tumor Heterogeneity of Aldosterone-Producing Adenoma.
Hypertension 81(2):361-371, 2023.
https://doi.org/10.1161/HYPERTENSIONAHA.123.21446
Sugawara SK, Yamamoto T, Nakayama Y, Hamano YH, Fukunaga M, Sadato N, Nishimura Y.
Premovement activity in the mesocortical system links peak force but not initiation of force generation under incentive motivation.
Cerebral Cortex 33(23):11408-11419, 2023.
https://doi.org/10.1093/cercor/bhad376
Park JH, Kawakami K, Ishimoto N, Ikuta T, Ohki M, Ekimoto T, Ikeguchi M, Lee DS, Lee YH, Tame JRH, Inoue A, Park SY.
Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.
Nat Commun 14(1):7150, 2023.
https://doi.org/10.1038/s41467-023-42764-8
Burghi V, Paradis JS, Officer A, Adame-Garcia SR, Wu X, Matthees ESF, Barsi-Rhyne B, Ramms DJ, Clubb L, Acosta M, Tamayo P, Bouvier M, Inoue A, von Zastrow M, Hoffmann C, Gutkind JS.
Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor.
J Biol Chem 299(11):105293, 2023.
https://doi.org/10.1016/j.jbc.2023.105293
Endo A, Imai J, Izumi T, Kawana Y, Sugawara H, Kohata M, Seike J, Kubo H, Komamura H, Sato T, Asai Y, Hosaka S, Kodama S, Takahashi K, Kaneko K, Katagiri H.
Phagocytosis by macrophages promotes pancreatic β cell mass reduction after parturition in mice.
Dev Cell 58(19):1819-1829, 2023.
https://doi.org/10.1016/j.devcel.2023.08.002
Ben-Shalom N, Sandbank E, Abramovitz L, Hezroni H, Levin T, Trachtenberg E, Fogel N, Mor M, Yefet R, Stoler-Barak L, Hagin D, Nakai A, Noda M, Suzuki K, Shulman Z, Ben-Elyiahu S, Freund, NT.
β2-adrenergic signaling promotes higher-affinity B cells and antibodies.
Brain Behav Immun 113:66-82, 2023.
https://doi.org/10.1016/j.bbi.2023.06.020
Sarma P, Carino CMC, Seetharama D, Pandey S, Dwivedi-Agnihotri H, Rui X, Cao Y, Kawakami K, Kumari P, Chen YC, Luker KE, Yadav PN, Luker GD, Laporte SA, Chen X, Inoue A, Shukla AK.
Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system.
Nat Commun 14(1):4808, 2023.
https://doi.org/10.1038/s41467-023-40482-9
Ono Y, Ito R, Arai K, Singh G, Saitoh T, Russell RB, Raimondi F, Aoki J, Sakai J, Inoue A.
Chemogenetic activation of G12 signaling enhances adipose tissue browning.
Signal Transduct Target Ther 8(1):307, 2023.
https://doi.org/10.1038/s41392-023-01524-2
Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y.
Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity.
Cell Res 33(8):644-647, 2023.
https://doi.org/10.1038/s41422-023-00835-x
Matic M, Miglionico P, Tatsumi M, Inoue A, Raimondi F.
GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach.
Nat Commun 14(1):4361, 2023.
https://doi.org/10.1038/s41467-023-40045-y
Ishimoto N, Park JH, Kawakami K, Tajiri M, Mizutani K, Akashi S, Tame JRH, Inoue A, Park SY.
Structural basis of CXC chemokine receptor 1 ligand binding and activation.
Nat Commun 14(1):4107, 2023.
https://doi.org/10.1038/s41467-023-39799-2
Bumbak F, Bower JB, Zemmer SC, Inoue A, Pons M, Paniagua JC, Yan F, Ford J, Wu H, Robson SA, Bathgate RAD, Scott DJ, Gooley PR, Ziarek JJ.
Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314.
Nat Commun 14(1):3328, 2023.
https://doi.org/10.1038/s41467-023-38894-8
Kobayashi K, Kawakami K, Kusakizako T, Tomita A, Nishimura M, Sawada K, Okamoto HH, Hiratsuka S, Nakamura G, Kuwabara R, Noda H, Muramatsu H, Shimizu M, Taguchi T, Inoue A, Murata T, Nureki O.
Class B1 GPCR activation by an intracellular agonist.
Nature 618(7967):1085-1093, 2023.
https://doi.org/10.1038/s41586-023-06169-3
Yahiro T, Kataoka N, Nakamura K.
Two Ascending Thermosensory Pathways from the Lateral Parabrachial Nucleus That Mediate Behavioral and Autonomous Thermoregulation.
J Neurosci 43(28):5221-5240, 2023.
https://doi.org/10.1523/JNEUROSCI.0643-23.2023
Sugawara H, Imai J, Yamamoto J, Izumi T, Kawana Y, Endo A, Kohata M, Seike J, Kubo H, Komamura H, Munakata Y, Asai Y, Hosaka S, Sawada S, Kodama S, Takahashi K, Kaneko K, Katagiri H.
A highly sensitive strategy for monitoring real-time proliferation of targeted cell types in vivo.
Nat Commun 14:3253, 2023.
https://doi.org/10.1038/s41467-023-38897-5
Tomita I, Tsuruta H, Yasuda-Yamahara M, Yamahara K, Kuwagata S, Tanaka-Sasaki Y, Chin-Kanasaki M, Fujita Y, Nishi E, Katagiri H, Maegawa H, Kume S.
Ketone bodies: A double-edged sword for mammalian life span.
Aging Cell 22(6):e13833, 2023.
https://doi.org/10.1111/acel.13833
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM.
Molecular mechanism of fatty acid activation of FFAR1.
Proc Natl Acad Sci U S A 120(22):e2219569120, 2023.
https://doi.org/10.1073/pnas.2219569120
Ogawa A, Ohira S, Kato Y, Ikuta T, Yanagida S, Mi X, Ishii Y, Kanda Y, Nishida M, Inoue A, Wei FY.
Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.
Commun Biol 6(1):511, 2023.
https://doi.org/10.1038/s42003-023-04888-x
Takahashi K, Yamada T, Hosaka S, Kaneko K, Asai Y, Munakata Y, Seike J, Horiuchi T, Kodama S, Izumi T, Sawada S, Hoshikawa K, Inoue J, Masamune A, Ueno Y, Imai J, Katagiri H.
Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages.
Cell Rep 42(5):112415, 2023.
https://doi.org/10.1016/j.celrep.2023.112415
Niitsu Y, Komiya C, Takeuchi A, Hara K, Horino M, Aoki J, Okazaki R, Murakami M, Tsujimoto K, Ikeda K, Yamada T.
Increased serum extracellular vesicle miR-144-3p and miR-486a-3p in a mouse model of adipose tissue regeneration promote hepatocyte proliferation by targeting Txnip.
PLoS One 18(5):e0284989, 2023.
https://doi.org/10.1371/journal.pone.0284989
Gao Y, Suito H, Chiba H, Nagayama M, Katagiri H.
Parameter estimation of the compartmental model of systemic circulation describing the Glucose, Insulin and C- peptide dynamics.
Proceedings of the Conference on Computational Engineering and Science 28(1):1-5, 2023.
Watanabe A, Koike H, Kumagami N, Shimba S, Manabe I, Oishi Y.
Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair.
Sci Rep 13(1):6747, 2023.
https://doi.org/10.1038/s41598-023-33830-8
Iio K, Hashimoto K, Nagumo Y, Amezawa M, Hasegawa T, Yamamoto N, Kutsumura N, Takeuchi K, Ishikawa Y, Yamamoto H, Tokuda A, Sato T, Uchida Y, Inoue A, Tanimura R, Yanagisawa M, Nagase H, Saitoh T.
Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
J Med Chem 66(8):5453-5464, 2023.
https://doi.org/10.1021/acs.jmedchem.2c01773
Heng J, Hu Y, Perez-Hernandez G, Inoue A, Zhao J, Ma X, Sun X, Kawakami K, Ikuta T, Ding J, Yang Y, Zhang L, Peng S, Niu X, Li H, Guixa-Gonzalez R, Jin C, Hildebrand PW, Chen C, Kobilka BK.
Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor.
Nat Commun 14(1):2005, 2023.
https://doi.org/10.1038/s41467-023-37233-1
Kjar VMS, Daugvilaite V, Stepniewski TM, Madsen CM, Jorgensen AS, Bhuskute KR, Inoue A, Ulven T, Benned-Jensen T, Hjorth SA, Hjorto GM, Moo EV, Selent J, Rosenkilde MM.
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization.
Sci Signal 16(779):eabl4283, 2023.
https://doi.org/10.1126/scisignal.abl4283
Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G.
Insights into distinct signaling profiles of the μOR activated by diverse agonists.
Nat Chem Biol 19(4):423-430, 2023.
https://doi.org/10.1038/s41589-022-01208-y
Tsuji S, Brace CS, Yao R, Tanie Y, Tada H, Rensing N, Mizuno S, Almunia J, Kong Y, Nakamura K, Furukawa T, Ogiso N, Toyokuni S, Takahashi S, Wong M, Imai SI, Satoh A.
Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice.
Life Sci Alliance 6(6):e202301992, 2023.
https://doi.org/10.26508/lsa.202301992
Garami A, Steiner AA, Pakai E, Wanner SP, Almeida MC, Keringer P, Oliveira DL, Nakamura K, Morrison SF, Romanovsky AA.
The neural pathway of the hyperthermic response to antagonists of the transient receptor potential vanilloid-1 channel.
Temperature 10(1):136-154, 2023.
https://doi.org/10.1080/23328940.2023.2171671
Shirai T, Nakai A, Ando E, Fujimoto J, Leach S, Arimori T, Higo D, van Eerden FJ, Tulyeu J, Liu YC, Okuzaki D, Murayama MA, Miyata H, Nunomura K, Lin B, Tani A, Kumanogoh A, Ikawa M, Wing JB, Standley DM, Takagi J, Suzuki K.
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
Sci Immunol 8(81):eadc9324, 2023.
https://doi.org/10.1126/sciimmunol.adc9324
Obara K, Kaneshige M, Suzuki M, Yokoyama O, Tazoe T, Nishimura Y.
Corticospinal interface to restore voluntary control of joint torque in a paralyzed forearm following spinal cord injury in non-human primates.
Front Neurosci 17:1127095, 2023.
https://doi.org/10.3389/fnins.2023.1127095
Liang J, Inoue A, Ikuta T, Xia R, Wang N, Kawakami K, Xu Z, Qian Y, Zhu X, Zhang A, Guo C, Huang Z, He Y.
Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation.
Nat Commun 14(1):1012, 2023.
https://doi.org/10.1038/s41467-023-36575-0
Cheng Y, Manabe I, Hayakawa S, Endo Y, Oishi Y.
Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages.
Front Immunol 14:1009973, 2023.
https://doi.org/10.3389/fimmu.2023.1009973
Ohue-Kitano R, Nonaka H, Nishida A, Masujima Y, Takahashi D, Ikeda T, Uwamizu A, Tanaka M, Kohjima M, Igarashi M, Katoh H, Tanaka T, Inoue A, Suganami T, Hase K, Ogawa Y, Aoki J, Kimura I.
Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84.
JCI Insight 8(2):e165469, 2023.
https://doi.org/10.1172/jci.insight.165469
Miyamoto J, Shimizu H, Hisa K, Matsuzaki C, Inuki S, Ando Y, Nishida A, Izumi A, Yamano M, Ushiroda C, Irie J, Katayama T, Ohno H, Itoh H, Yamamoto K, Kimura I.
Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides.
Gut Microbes 15(1):2161271, 2023.
https://doi.org/10.1080/19490976.2022.2161271
Ono Y, Kawakami K, Nakamura G, Ishida S, Aoki J, Inoue A.
Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs.
Commun Biol 6(1):112, 2023.
https://doi.org/10.1038/s42003-023-04465-2
Xu J, Wang Q, Hubner H, Hu Y, Niu X, Wang H, Maeda S, Inoue A, Tao Y, Gmeiner P, Du Y, Jin C, Kobilka BK.
Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nat Commun 14(1):376, 2023.
https://doi.org/10.1038/s41467-022-35726-z
Tatsumi M, Kishi T, Ishida S, Kawana H, Uwamizu A, Ono Y, Kawakami K, Aoki J, Inoue A.
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.
PLoS One 18(1):e0280448, 2023.
https://doi.org/10.1371/journal.pone.0280448
Niizawa T, Sakuraba R, Kusaka T, Kurihara Y, Sugashi T, Kawaguchi H, Kanno I, Masamoto K.
Spatiotemporal analysis of blood plasma and blood cell flow fluctuations of cerebral microcirculation in anesthetized rats.
J Cereb Blood Flow Metab 43(1):138-152, 2023.
https://doi.org/10.1177/0271678X221125743

総説

Katagiri H.
Inter-organ communication involved in metabolic regulation at the whole-body level.
Inflamm Regen 43(1):60, 2023.
https://doi.org/10.1161/10.1186/s41232-023-00306-1

2022

原著論文

Hara K, Murakami M, Niitsu Y, Takeuchi A, Horino M, Shiba K, Tsujimoto K, Komiya C, Ikeda K, Tsuiki M, Tanabe A, Tanaka T, Yokoyama M, Fujii Y, Naruse M, Yamada T.
Heterogeneous circulating miRNA profiles of PBMAH.
Front Endocrinol (Lausanne) 13:1073328, 2022.
https://doi.org/10.3389/fendo.2022.1073328
Nakamura Y, Yahiro T, Fukushima A, Kataoka N, Hioki H, Nakamura K.
Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling.
Sci Adv 8(51):eadd5463, 2022.
https://doi.org/10.1126/sciadv.add5463
Kaneshige M, Obara K, Suzuki M, Tazoe T, Nishimura Y.
Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys.
Elife 11:e78346, 2022.
https://doi.org/10.7554/eLife.78346
Umeda T, Isa T, Nishimura Y.
Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement.
Proc Natl Acad Sci U S A 119(48):e2208353119, 2022.
https://doi.org/10.1073/pnas.2208353119
Nawaz A, Bilal M, Fujisaka S, Kado T, Aslam MR, Ahmed S, Okabe K, Igarashi Y, Watanabe Y, Kuwano T, Tsuneyama K, Nishimura A, Nishida Y, Yamamoto S, Sasahara M, Imura J, Mori H, Matzuk MM, Kudo F, Manabe I, Uezumi A, Nakagawa T, Oishi Y, Tobe K.
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration.
Nat Commun 13(1):7058, 2022.
https://doi.org/10.1038/s41467-022-34191-y
Hayakawa S, Tamura A, Nikiforov N, Koike H, Kudo F, Cheng Y, Miyazaki T, Kubekina M, Kirichenko TV, Orekhov AN, Yui N, Manabe I, Oishi Y.
Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling.
JCI Insight 7(22):e138539, 2022.
https://doi.org/10.1172/jci.insight.138539
Janetzko J, Kise R, Barsi-Rhyne B, Siepe DH, Heydenreich FM, Kawakami K, Masureel M, Maeda S, Garcia KC, von Zastrow M, Inoue A, Kobilka BK.
Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.
Cell 185(24):4560-4573.e19, 2022.
https://doi.org/10.1016/j.cell.2022.10.018
Kubo H, Sawada S, Satoh M, Asai Y, Kodama S, Sato T, Tomiyama S, Seike J, Takahashi K, Kaneko K, Imai J, Katagiri H.
Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study.
Sci Rep 12(1):20130, 2022.
https://doi.org/10.1038/s41598-022-23521-1
Kohata M, Imai J, Izumi T, Yamamoto J, Kawana Y, Endo A, Sugawara H, Seike J, Kubo H, Komamura H, Sato T, Hosaka S, Munakata Y, Asai Y, Kodama S, Takahashi K, Kaneko K, Katagiri H.
Roles of FoxM1-driven basal β-cell proliferation in maintenance of β-cell mass and glucose tolerance during adulthood.
J Diabetes Investig 13(10):1666-1676, 2022.
https://doi.org/10.1111/jdi.13846
Usuda N, Sugawara SK, Fukuyama H, Nakazawa K, Amemiya K, Nishimura Y.
Quantitative comparison of corticospinal tracts arising from different cortical areas in humans.
Neurosci Res 183:30-49, 2022.
https://doi.org/10.1016/j.neures.2022.06.008
Suno R, Sugita Y, Morimoto K, Takazaki H, Tsujimoto H, Hirose M, Suno-Ikeda C, Nomura N, Hino T, Inoue A, Iwasaki K, Kato T, Iwata S, Kobayashi T.
Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex.
Cell Rep 40(11):111323, 2022.
https://doi.org/10.1016/j.celrep.2022.111323
Walker AR, Larsen CB, Kundu S, Stavrinidis C, Kim SH, Inoue A, Woodward DF, Lee YS, Migale R, MacIntyre DA, Terzidou V, Fanelli F, Khanjani S, Bennett PR, Hanyaloglu AC.
Functional rewiring of G protein-coupled receptor signaling in human labor.
Cell Rep 40(10):111318, 2022.
https://doi.org/10.1016/j.celrep.2022.111318
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O.
Endogenous ligand recognition and structural transition of a human PTH receptor.
Mol Cell 82(18):3468-3483.e5, 2022.
https://doi.org/10.1016/j.molcel.2022.07.003
Fukushima A, Kataoka N, Nakamura K.
An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflows.
Cell Rep 40(12):111380, 2022.
https://doi.org/10.1016/j.celrep.2022.111380
Kawai K, Tazoe T, Yanai T, Kanosue K, Nishimura Y.
Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation.
Front Hum Neurosci 16:1016064, 2022.
https://doi.org/10.3389/fnhum.2022.1016064
Suzuki M, Nishimura Y.
The ventral striatum contributes to the activity of the motor cortex and motor outputs in monkeys.
Front Syst Neurosci 16:979272, 2022.
https://doi.org/10.3389/fnsys.2022.979272
Koba S, Kumada N, Narai E, Kataoka N, Nakamura K, Watanabe T.
A brainstem circuit coordinating locomotor activities and sympathetic cardiovascular responses.
Nat Commun 13(1):5079, 2022.
https://doi.org/10.1038/s41467-022-32823-x
Baidya M, Chaturvedi M, Dwivedi-Agnihotri H, Ranjan A, Devost D, Namkung Y, Stepniewski TM, Pandey S, Baruah M, Panigrahi B, Sarma P, Yadav MK, Maharana J, Banerjee R, Kawakami K, Inoue A, Selent J, Laporte SA, Hebert TE, Shukla AK.
Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody.
Nat Commun 13(1):4634, 2022.
https://doi.org/10.1038/s41467-022-32386-x
Heo Y, Ishimoto N, Jeon YE, Yun JH, Ohki M, Anraku Y, Sasaki M, Kita S, Fukuhara H, Ikuta T, Kawakami K, Inoue A, Maenaka K, Tame JRH, Lee W, Park SY.
Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.
PLoS Biol 20(8):e3001714, 2022.
https://doi.org/10.1371/journal.pbio.3001714
Nakayama Y, Sugawara SK, Fukunaga M, Hamano YH, Sadato N, Nishimura Y.
The dorsal premotor cortex encodes the step-by-step planning processes for goal-directed motor behavior in humans.
Neuroimage 256:119221, 2022.
https://doi.org/10.1016/j.neuroimage.2022.119221
Ikegame S,Yoshimoto M, Miki K.
Simultaneous measurement of central amygdala neuronal activity and sympathetic nerve activity during daily activities in rats.
Exp Physiol 107(9):1071-1080, 2022.
https://doi.org/10.1113/EP090538
Dixon AD, Inoue A, Robson SA, Culhane KJ, Trinidad JC, Sivaramakrishnan S, Bumbak F, Ziarek JJ.
Effect of Ligands and Transducers on the Neurotensin Receptor 1 Conformational Ensemble.
J Am Chem Soc 144(23):10241-10250, 2022.
https://doi.org/10.1021/jacs.2c00828
Nureki I, Kobayashi K, Tanaka T, Demura K, Inoue A, Shihoya W, Nureki O.
Cryo-EM structures of the β3 adrenergic receptor bound to solabegron and isoproterenol.
Biochem Biophys Res Commun 611:158-164, 2022.
https://doi.org/10.1016/j.bbrc.2022.04.065
Matic M, Singh G, Carli F, Oliveira Rosa N, Miglionico P, Magni L, Gutkind JS, Russell RB, Inoue A, Raimondi F.
PRECOGx: exploring GPCR signaling mechanisms with deep protein representations.
Nucleic Acids Res 50(W1):W598-W610, 2022.
https://doi.org/10.1093/nar/gkac426
El Khamlichi C, Reverchon F, Hervouet-Coste N, Robin E, Chopin N, Deau E, Madouri F, Guimpied C, Colas C, Menuet A, Inoue A, Bojarski AJ, Guillaumet G, Suzenet F, Reiter E, Morisset-Lopez S.
Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors.
Proc Natl Acad Sci U S A 119(21):e2118847119, 2022.
https://doi.org/10.1073/pnas.2118847119
Ninomiya T, Nakagawa H, Inoue KI, Nishimura Y, Oishi T, Yamashita T, Takada M.
Origin of Multisynaptic Corticospinal Pathway to Forelimb Segments in Macaques and Its Reorganization After Spinal Cord Injury.
Front Neural Circuits 16:847100, 2022.
https://doi.org/10.3389/fncir.2022.847100
Miki K, Ikegame S, Yoshimoto M.
Regional differences in sympathetic nerve activity are generated by multiple arterial baroreflex loops arranged in parallel.
Front Physiol 13:858654, 2022.
https://doi.org/10.3389/fphys.2022.858654
Nonaka H, Ohue-Kitano R, Masujima Y, Igarashi M, Kimura I.
Dietary medium-chain triglyceride decanoate affects glucose homeostasis through GPR84-mediated GLP-1 secretion in mice.
Front Nutr 9:e848450, 2022.
https://doi.org/10.3389/fnut.2022.848450
Yakubo K, Fujiki Y.
A general model of hierarchical fractal scale-free networks.
PLoS One 17(3):e0264589, 2022.
https://doi.org/10.1371/journal.pone.0264589
Zheng K, Smith JS, Eiger DS, Warman A, Choi I, Honeycutt CC, Boldizsar N, Gundry JN, Pack TF, Inoue A, Caron MG, Rajagopal S.
Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes.
Sci Signal 15(726):eabg5203, 2022.
https://doi.org/10.1126/scisignal.abg5203
Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y.
Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism.
Nat Chem Biol 18(3):281-288, 2022.
https://doi.org/10.1038/s41589-021-00930-3
Yuzawa R, Koike H, Manabe I, Oishi Y.
VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes.
Sci Rep 12(1):1377, 2022.
https://doi.org/10.1038/s41598-022-05354-0
Yasugahira Y, Nagayama M.
On a numerical bifurcation analysis of a particle reaction‐diffusion model for a motion of two self‐propelled disks.
Jpn J Ind Appl Math 39:631-652, 2022.
https://doi.org/10.1007/s13160-021-00498-4
Kawakami K, Yanagawa M, Hiratsuka S, Yoshida M, Ono Y, Hiroshima M, Ueda M, Aoki J, Sako Y, Inoue A.
Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias.
Nat Commun 13(1):487, 2022.
https://doi.org/10.1038/s41467-022-28056-7
Iio K, Kutsumura N, Nagumo Y, Saitoh T, Tokuda A, Hashimoto K, Yamamoto N, Kise R, Inoue A, Mizoguchi H, Nagase H.
Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.
Bioorg Med Chem Lett 56:128485, 2022.
https://doi.org/10.1016/j.bmcl.2021.128485

総説

Ikeda T, Nishida A, Yamano M, Kimura I.
Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases.
Pharmacol Therapeut 239:108273, 2022.
https://doi.org/10.1016/j.pharmthera.2022.108273
Horino M, Ikeda K, Yamada T.
The Role of Thermogenic Fat Tissue in Energy Consumption.
Curr Issues Mol Biol 44(7):3166-3179, 2022.
https://doi.org/10.3390/cimb44070219
Morrison SF, Nakamura K, Tupone D.
Thermoregulation in mice: The road to understanding torpor hypothermia and the shortcomings of a circuit for generating fever.
Temperature (Austin) 9(1):8-11, 2022.
https://doi.org/10.1080/23328940.2021.2021059
Imai J, Katagiri H.
Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation.
Int Immunol 34(2):67-79, 2022.
https://doi.org/10.1093/intimm/dxab023
Nakamura K, Morrison SF.
Central sympathetic network for thermoregulatory responses to psychological stress.
Auton Neurosci 237:102918, 2022.
https://doi.org/10.1016/j.autneu.2021.102918
Nakamura K, Nakamura Y, Kataoka N.
A hypothalamomedullary network for physiological responses to environmental stresses.
Nat Rev Neurosci 23(1):35-52, 2022.
https://doi.org/10.1038/s41583-021-00532-x
Fujiu K, Manabe I.
Nerve-macrophage interactions in cardiovascular disease.
Int Immunol 34(2):81-95, 2022.
https://doi.org/10.1093/intimm/dxab036

2021

原著論文

Pandey S, Kumari P, Baidya M, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li XX, Cui CS, Lee JD, Kawakami K, Chaturvedi M, Ranjan A, Laporte SA, Woodruff TM, Inoue A, Shukla AK.
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.
Mol Cell 81(18):1-17, 2021.
https://doi.org/10.1016/j.molcel.2021.09.007
Liu L, Koike H, Ono T, Hayashi S, Kudo F, Kaneda A, Kagechika H, Manabe I, Nakashima T, Oishi Y.
Identification of a novel KLF5-dependent program and drug development for skeletal muscle atrophy.
Proc Natl Acad Sci U S A 118(35):e2102895118, 2021.
https://doi.org/10.1073/pnas.2102895118
Watanabe K, Yamano M, Masujima Y, Ohue-Kitano R, Kimura I.
Curdlan intake changes gut microbial composition, short-chain fatty acid production, and bile acid transformation in mice.
Biochem Biophys Rep 27:101095, 2021.
https://doi.org/10.1016/j.bbrep.2021.101095
McGlone ER, Manchanda Y, Jones B, Pickford P, Inoue A, Carling D, Bloom SR, Tan T, Tomas A.
Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.
Mol Metab 53:101296, 2021.
https://doi.org/10.1016/j.molmet.2021.101296
Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M, Crown SB, Osawa T, Sakai J, McGarrah RW, White PJ, Nakamura K, Kajimura S.
Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever.
Elife 10:e66865, 2021.
https://doi.org/10.7554/eLife.66865
Chiba H.
A Hopf bifurcation in the Kuramoto-Daido model.
J Diff Equ 280:545-570, 2021.
https://doi.org/10.1016/j.jde.2021.01.024
Kubota SI, Takahashi K, Mano T, Matsumoto K, Katsumata T, Shi S, Tainaka K, Ueda HR, Ehata S, Miyazono K.
Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing.
Commun Biol 4(1):294, 2021.
https://doi.org/10.1038/s42003-021-01786-y
Iwama T, Kano K, Saigusa D, Ekroos K, van Echten-Deckert G, Vogt J, Aoki J.
Development of an On-Tissue Derivatization Method for MALDI Mass Spectrometry Imaging of Bioactive Lipids Containing Phosphate Monoester Using Phos-tag.
Anal Chem 93(8):3867-3875, 2021.
https://doi.org/10.1021/acs.analchem.0c04479
Adachi Y, Ota K, Minami I, Yamada T, Watanabe T.
Lower Insulin Secretion Is Associated with Hippocampal and Parahippocampal Gyrus Atrophy in Elderly Patients with Type 2 Diabetes Mellitus.
J Diabetes Investig 12(10):1908-1913, 2021.
https://doi.org/10.1111/jdi.13554
Nakamaru R, Yamamoto K, Akasaka H, Rakugi H, Kurihara I, Yoneda T, Ichijo T, Katabami T, Tsuiki M, Wada N, Yamada T, Kobayashi H, Tamura K, Ogawa Y, Kawashima J, Inagaki N, Fujita M, Watanabe M, Kamemura K, Okamura S, Tanabe A, Naruse M; JPAS/JRAS Study Group.
Age-stratified comparison of clinical outcomes between medical and surgical treatments in patients with unilateral primary aldosteronism.
Sci Rep 11(1):6925, 2021.
https://doi.org/10.1038/s41598-021-86290-3
Kotani K, Akao A, Chiba H.
Bifurcation of the neuronal population dynamics of the modified theta model: transition to macroscopic gamma oscillation.
Physica D 416:132789, 2021.
https://doi.org/10.1016/j.physd.2020.132789
Fukuda T, Bouchi R, Takeuchi T, Amo-Shiinoki K, Kudo A, Tanaka S, Tanabe M, Akashi T, Hirayama K, Odamaki T, Igarashi M, Kimura I, Tanabe K, Tanizawa Y, Yamada T, Ogawa Y.
Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes.
Diabetes Care 44(4):1002-1011, 2021.
https://doi.org/10.2337/dc20-0864
Nakamaru R, Yamamoto K, Akasaka H, Rakugi H, Kurihara I, Yoneda T, Ichijo T, Katabami T, Tsuiki M, Wada N, Yamada T, Kobayashi H, Tamura K, Ogawa Y, Kawashima J, Inagaki N, Fujita M, Oki K, Kamemura K, Tanabe A, Naruse M; JPAS/JRAS study group.
Sex Differences in Renal Outcomes After Medical Treatment for Bilateral Primary Aldosteronism.
Hypertension 77(2):537-545, 2021.
https://doi.org/10.1161/HYPERTENSIONAHA.120.16449
Kano K, Matsumoto H, Kono N, Kurano M, Yatomi Y, Aoki J.
Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification.
J Lipid Res 62:100029, 2021.
https://doi.org/10.1016/j.jlr.2021.100029
Amo-Shiinoki K, Tanabe K, Hoshii Y, Matsui H, Harano R, Fukuda T, Takeuchi T, Bouchi R, Takagi T, Hatanaka M, Takeda K, Okuya S, Nishimura W, Kudo A, Tanaka S, Tanabe M, Akashi T, Yamada T, Ogawa Y, Ikeda E, Nagano H, Tanizawa Y.
Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes.
JCI Insight 6(1):e143791, 2021.
https://doi.org/10.1172/jci.insight.143791
Bouchi R, Sonoda N, Itoh J, Ono Y, Fukuda T, Takeuchi T, Kishimoto J, Yamada T, Ogawa Y.
Effects of intensive exercise combined with dapagliflozin on body composition in patients with type 2 diabetes: a randomized controlled trial.
Endocr J 68(3):329-343, 2021.
https://doi.org/10.1507/endocrj.EJ20-0599

総説

Richardson DS, Guan W, Matsumoto K, Pan C, Chung K, Erturk A, Ueda HR, Lichtman JW.
Tissue clearing.
Nat Rev Methods Primers 1(1):84, 2021.
https://doi.org/10.1038/s43586-021-00080-9
Nakai A, Leach S, Suzuki K.
Control of immune cell trafficking through inter-organ communication.
Int Immunol 33(6):327-335, 2021.
https://doi.org/10.1093/intimm/dxab009

論評

Kume S.
Ketone bodies: back to a place in the sun.
Kidney Int 100(5):976-978, 2021.
https://doi.org/10.1016/j.kint.2021.07.022

2020

原著論文

Kawahori K, Kondo Y, Yuan X, Kawasaki Y, Hanzawa N, Tsujimoto K, Wada F, Kohda T, Ishigami A, Yamada T, Ogawa Y, Hashimoto K.
Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver.
Sci Rep 10(1):21228, 2020.
https://doi.org/10.1038/s41598-020-77962-7