ムーンショット型研究開発事業 目標2:2050年までに超早期に疾患の予測・予防をすることができる社会を実現 恒常性の理解と制御による糖尿病および併発疾患の克服 プロジェクトマネージャー(PM):片桐秀樹(東北大学大学院医学系研究科 教授)

研究成果

2024 | 2023 | 2022 | 2021 | 2020

2024

原著論文

  • Nakayama Y, Fujiu K, Oshima T, Matsuda J, Sugita J, Matsubara TJ, Liu Y, Goto K, Kani K, Uchida R, Takeda N, Morita H, Xiao Y, Hayashi M, Maru Y, Hasumi E, Kojima T, Ishiguro S, Kijima Y, Yachie N, Yamazaki S, Yamamoto R, Kudo F, Nakanishi M, Iwama A, Fujiki R, Kaneda A, Ohara O, Nagai R, Manabe I, Komuro I.
    Heart failure promotes multimorbidity through innate immune memory.
    Sci Immunol 9(95):eade3814, 2024.
    https://doi.org/10.1126/sciimmunol.ade3814
  • McNeill SM, Lu J, Marion C Carino C, Inoue A, Zhao P, Sexton PM, Wootten D.
    The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation.
    Biochem Pharmacol 222:116119, 2024.
    https://doi.org/10.1016/j.bcp.2024.116119
  • Zecchin D, Knopfel N, Gluck AK, Stevenson M, Sauvadet A, Polubothu S, Barberan-Martin S, Michailidis F, Bryant D, Inoue A, Lines KE, Hannan FM, Semple RK, Thakker RV, Kinsler VA.
    GNAQ/GNA11 Mosaicism Causes Aberrant Calcium Signaling Susceptible to Targeted Therapeutics.
    J Invest Dermatol 144(4):811-819, 2024.
    https://doi.org/10.1016/j.jid.2023.08.028
  • Oya M, Miyasaka Y, Nakamura Y, Tanaka M, Suganami T, Mashimo T, Nakamura K.
    Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia.
    Cell Metab 36(5):1044-1058, 2024.
    https://doi.org/10.1016/j.cmet.2024.02.010
  • Ham D, Inoue A, Xu J, Du Y, Chung KY.
    Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq.
    Commun Biol 7(1):362, 2024.
    https://doi.org/10.1038/s42003-024-06056-1
  • Chen G, Staffen N, Wu Z, Xu X, Pan J, Inoue A, Shi T, Gmeiner P, Du Y, Xu J.
    Structural and functional characterization of the endogenous agonist for orphan receptor GPR3.
    Cell Res 34(3):262-265, 2024.
    https://doi.org/10.1038/s41422-023-00919-8
  • Imamura K, Akagi KI, Miyanoiri Y, Tsujimoto H, Hirokawa T, Ashida H, Murakami K, Inoue A, Suno R, Ikegami T, Sekiyama N, Iwata S, Kobayashi T, Tochio H.
    Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy.
    Structure 32(3):352-361, 2024.
    https://doi.org/10.1016/j.str.2023.12.008
  • Onodera K, Hasegawa Y, Yokota N, Tamura S, Kinno H, Takahashi I, Chiba H, Kojima H, Katagiri H, Nata K, Ishigaki Y
    A newly identified compound activating UCP1 inhibits obesity and its related metabolic disorders.
    Obesity 32(2):324-338, 2024.
    https://doi.org/10.1002/oby.23948
  • Jayakody T, Inoue A, Kannan S, Nakamura G, Kawakami K, Mendis K, Nguyen TB, Li J, Herr DR, Verma CS, Dawe GS.
    Mechanisms of biased agonism by Gαi/o-biased stapled peptide agonists of the relaxin-3 receptor.
    Sci Signal 17(823):eabl5880, 2024.
    https://doi.org/10.1126/scisignal.abl5880
  • Kajitani N, Okada-Tsuchioka M, Inoue A, Miyano K, Masuda T, Boku S, Iwamoto K, Ohtsuki S, Uezono Y, Aoki J, Takebayashi M.
    G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression.
    Neuropsychopharmacology 49(3):561-572, 2024.
    https://doi.org/10.1038/s41386-023-01727-9
  • Moller TC, Moo EV, Inoue A, Pedersen MF, Brauner-Osborne H.
    Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins.
    Biochim Biophys Acta Mol Cell Res 1871(1):119584, 2024.
    https://doi.org/10.1016/j.bbamcr.2023.119584
  • Oishi Y, Koike H, Kumagami N, Nakagawa Y, Araki M, Taketomi Y, Miki Y, Matsuda S, Matsuzaka T, Ozawa H, Shimano H, Murakami M, Manabe I.
    Macrophage SREBP1 regulates skeletal muscle regeneration.
    Front Immunol 14:1251784, 2024.
    https://doi.org/10.3389/fimmu.2023.1251784

総説

2023

原著論文

  • Abdelwahid MAS, Ohsawa K, Uwamizu A, Kano K, Aoki J, Doi T.
    Synthesis and Biological Evaluation of Lysophosphatidic Acid Analogues Using Conformational Restriction and Bioisosteric Replacement Strategies.
    ACS Omega 8(51):49278-49288, 2023.
    https://doi.org/10.1021/acsomega.3c07668
  • Murakami M, Hara K, Ikeda K, Horino M, Okazaki R, Niitsu Y, Takeuchi A, Aoki J, Shiba K, Tsujimoto K, Komiya C, Nakamura Y, Kurata M, Akashi T, Fujii Y, Yamada T.
    Single-Nuclei Analysis Reveals Tumor Heterogeneity of Aldosterone-Producing Adenoma.
    Hypertension 81(2):361-371, 2023.
    https://doi.org/10.1161/HYPERTENSIONAHA.123.21446
  • Sugawara SK, Yamamoto T, Nakayama Y, Hamano YH, Fukunaga M, Sadato N, Nishimura Y.
    Premovement activity in the mesocortical system links peak force but not initiation of force generation under incentive motivation.
    Cerebral Cortex 33(23):11408-11419, 2023.
    https://doi.org/10.1093/cercor/bhad376
  • Park JH, Kawakami K, Ishimoto N, Ikuta T, Ohki M, Ekimoto T, Ikeguchi M, Lee DS, Lee YH, Tame JRH, Inoue A, Park SY.
    Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.
    Nat Commun 14(1):7150, 2023.
    https://doi.org/10.1038/s41467-023-42764-8
  • Burghi V, Paradis JS, Officer A, Adame-Garcia SR, Wu X, Matthees ESF, Barsi-Rhyne B, Ramms DJ, Clubb L, Acosta M, Tamayo P, Bouvier M, Inoue A, von Zastrow M, Hoffmann C, Gutkind JS.
    Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor.
    J Biol Chem 299(11):105293, 2023.
    https://doi.org/10.1016/j.jbc.2023.105293
  • Kawana Y, Imai J, Morizawa YM, Ikoma Y, Kohata M, Komamura H, Sato T, Izumi T, Yamamoto J, Endo A, Sugawara H, Kubo H, Hosaka S, Munakata Y, Asai Y, Kodama S, Takahashi K, Kaneko K, Sawada S, Yamada T, Ito A, Niizuma K, Tominaga T, Yamanaka A, Matsui K, Katagiri H.
    Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation.
    Nat Biomed Eng Online ahead of print, 2023.
    https://doi.org/10.1038/s41551-023-01113-2
  • Endo A, Imai J, Izumi T, Kawana Y, Sugawara H, Kohata M, Seike J, Kubo H, Komamura H, Sato T, Asai Y, Hosaka S, Kodama S, Takahashi K, Kaneko K, Katagiri H.
    Phagocytosis by macrophages promotes pancreatic β cell mass reduction after parturition in mice.
    Dev Cell 58(19):1819-1829, 2023.
    https://doi.org/10.1016/j.devcel.2023.08.002
  • Ben-Shalom N, Sandbank E, Abramovitz L, Hezroni H, Levin T, Trachtenberg E, Fogel N, Mor M, Yefet R, Stoler-Barak L, Hagin D, Nakai A, Noda M, Suzuki K, Shulman Z, Ben-Elyiahu S, Freund, NT.
    β2-adrenergic signaling promotes higher-affinity B cells and antibodies.
    Brain Behav Immun 113:66-82, 2023.
    https://doi.org/10.1016/j.bbi.2023.06.020
  • Sarma P, Carino CMC, Seetharama D, Pandey S, Dwivedi-Agnihotri H, Rui X, Cao Y, Kawakami K, Kumari P, Chen YC, Luker KE, Yadav PN, Luker GD, Laporte SA, Chen X, Inoue A, Shukla AK.
    Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system.
    Nat Commun 14(1):4808, 2023.
    https://doi.org/10.1038/s41467-023-40482-9
  • Ono Y, Ito R, Arai K, Singh G, Saitoh T, Russell RB, Raimondi F, Aoki J, Sakai J, Inoue A.
    Chemogenetic activation of G12 signaling enhances adipose tissue browning.
    Signal Transduct Target Ther 8(1):307, 2023.
    https://doi.org/10.1038/s41392-023-01524-2
  • Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y.
    Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity.
    Cell Res 33(8):644-647, 2023.
    https://doi.org/10.1038/s41422-023-00835-x
  • Matic M, Miglionico P, Tatsumi M, Inoue A, Raimondi F.
    GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach.
    Nat Commun 14(1):4361, 2023.
    https://doi.org/10.1038/s41467-023-40045-y
  • Ishimoto N, Park JH, Kawakami K, Tajiri M, Mizutani K, Akashi S, Tame JRH, Inoue A, Park SY.
    Structural basis of CXC chemokine receptor 1 ligand binding and activation.
    Nat Commun 14(1):4107, 2023.
    https://doi.org/10.1038/s41467-023-39799-2
  • Bumbak F, Bower JB, Zemmer SC, Inoue A, Pons M, Paniagua JC, Yan F, Ford J, Wu H, Robson SA, Bathgate RAD, Scott DJ, Gooley PR, Ziarek JJ.
    Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314.
    Nat Commun 14(1):3328, 2023.
    https://doi.org/10.1038/s41467-023-38894-8
  • Kobayashi K, Kawakami K, Kusakizako T, Tomita A, Nishimura M, Sawada K, Okamoto HH, Hiratsuka S, Nakamura G, Kuwabara R, Noda H, Muramatsu H, Shimizu M, Taguchi T, Inoue A, Murata T, Nureki O.
    Class B1 GPCR activation by an intracellular agonist.
    Nature 618(7967):1085-1093, 2023.
    https://doi.org/10.1038/s41586-023-06169-3
  • Yahiro T, Kataoka N, Nakamura K.
    Two Ascending Thermosensory Pathways from the Lateral Parabrachial Nucleus That Mediate Behavioral and Autonomous Thermoregulation.
    J Neurosci 43(28):5221-5240, 2023.
    https://doi.org/10.1523/JNEUROSCI.0643-23.2023
  • Sugawara H, Imai J, Yamamoto J, Izumi T, Kawana Y, Endo A, Kohata M, Seike J, Kubo H, Komamura H, Munakata Y, Asai Y, Hosaka S, Sawada S, Kodama S, Takahashi K, Kaneko K, Katagiri H.
    A highly sensitive strategy for monitoring real-time proliferation of targeted cell types in vivo.
    Nat Commun 14:3253, 2023.
    https://doi.org/10.1038/s41467-023-38897-5
  • Tomita I, Tsuruta H, Yasuda-Yamahara M, Yamahara K, Kuwagata S, Tanaka-Sasaki Y, Chin-Kanasaki M, Fujita Y, Nishi E, Katagiri H, Maegawa H, Kume S.
    Ketone bodies: A double-edged sword for mammalian life span.
    Aging Cell 22(6):e13833, 2023.
    https://doi.org/10.1111/acel.13833
  • Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM.
    Molecular mechanism of fatty acid activation of FFAR1.
    Proc Natl Acad Sci U S A 120(22):e2219569120, 2023.
    https://doi.org/10.1073/pnas.2219569120
  • Ogawa A, Ohira S, Kato Y, Ikuta T, Yanagida S, Mi X, Ishii Y, Kanda Y, Nishida M, Inoue A, Wei FY.
    Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.
    Commun Biol 6(1):511, 2023.
    https://doi.org/10.1038/s42003-023-04888-x
  • Takahashi K, Yamada T, Hosaka S, Kaneko K, Asai Y, Munakata Y, Seike J, Horiuchi T, Kodama S, Izumi T, Sawada S, Hoshikawa K, Inoue J, Masamune A, Ueno Y, Imai J, Katagiri H.
    Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages.
    Cell Rep 42(5):112415, 2023.
    https://doi.org/10.1016/j.celrep.2023.112415
  • Niitsu Y, Komiya C, Takeuchi A, Hara K, Horino M, Aoki J, Okazaki R, Murakami M, Tsujimoto K, Ikeda K, Yamada T.
    Increased serum extracellular vesicle miR-144-3p and miR-486a-3p in a mouse model of adipose tissue regeneration promote hepatocyte proliferation by targeting Txnip.
    PLoS One 18(5):e0284989, 2023.
    https://doi.org/10.1371/journal.pone.0284989
  • Gao Y, Suito H, Chiba H, Nagayama M, Katagiri H.
    Parameter estimation of the compartmental model of systemic circulation describing the Glucose, Insulin and C- peptide dynamics.
    Proceedings of the Conference on Computational Engineering and Science 28(1):1-5, 2023.
  • Watanabe A, Koike H, Kumagami N, Shimba S, Manabe I, Oishi Y.
    Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair.
    Sci Rep 13(1):6747, 2023.
    https://doi.org/10.1038/s41598-023-33830-8
  • Iio K, Hashimoto K, Nagumo Y, Amezawa M, Hasegawa T, Yamamoto N, Kutsumura N, Takeuchi K, Ishikawa Y, Yamamoto H, Tokuda A, Sato T, Uchida Y, Inoue A, Tanimura R, Yanagisawa M, Nagase H, Saitoh T.
    Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
    J Med Chem 66(8):5453-5464, 2023.
    https://doi.org/10.1021/acs.jmedchem.2c01773
  • Heng J, Hu Y, Perez-Hernandez G, Inoue A, Zhao J, Ma X, Sun X, Kawakami K, Ikuta T, Ding J, Yang Y, Zhang L, Peng S, Niu X, Li H, Guixa-Gonzalez R, Jin C, Hildebrand PW, Chen C, Kobilka BK.
    Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor.
    Nat Commun 14(1):2005, 2023.
    https://doi.org/10.1038/s41467-023-37233-1
  • Kjar VMS, Daugvilaite V, Stepniewski TM, Madsen CM, Jorgensen AS, Bhuskute KR, Inoue A, Ulven T, Benned-Jensen T, Hjorth SA, Hjorto GM, Moo EV, Selent J, Rosenkilde MM.
    Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization.
    Sci Signal 16(779):eabl4283, 2023.
    https://doi.org/10.1126/scisignal.abl4283
  • Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G.
    Insights into distinct signaling profiles of the μOR activated by diverse agonists.
    Nat Chem Biol 19(4):423-430, 2023.
    https://doi.org/10.1038/s41589-022-01208-y
  • Tsuji S, Brace CS, Yao R, Tanie Y, Tada H, Rensing N, Mizuno S, Almunia J, Kong Y, Nakamura K, Furukawa T, Ogiso N, Toyokuni S, Takahashi S, Wong M, Imai SI, Satoh A.
    Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice.
    Life Sci Alliance 6(6):e202301992, 2023.
    https://doi.org/10.26508/lsa.202301992
  • Garami A, Steiner AA, Pakai E, Wanner SP, Almeida MC, Keringer P, Oliveira DL, Nakamura K, Morrison SF, Romanovsky AA.
    The neural pathway of the hyperthermic response to antagonists of the transient receptor potential vanilloid-1 channel.
    Temperature 10(1):136-154, 2023.
    https://doi.org/10.1080/23328940.2023.2171671
  • Shirai T, Nakai A, Ando E, Fujimoto J, Leach S, Arimori T, Higo D, van Eerden FJ, Tulyeu J, Liu YC, Okuzaki D, Murayama MA, Miyata H, Nunomura K, Lin B, Tani A, Kumanogoh A, Ikawa M, Wing JB, Standley DM, Takagi J, Suzuki K.
    Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
    Sci Immunol 8(81):eadc9324, 2023.
    https://doi.org/10.1126/sciimmunol.adc9324
  • Obara K, Kaneshige M, Suzuki M, Yokoyama O, Tazoe T, Nishimura Y.
    Corticospinal interface to restore voluntary control of joint torque in a paralyzed forearm following spinal cord injury in non-human primates.
    Front Neurosci 17:1127095, 2023.
    https://doi.org/10.3389/fnins.2023.1127095
  • Liang J, Inoue A, Ikuta T, Xia R, Wang N, Kawakami K, Xu Z, Qian Y, Zhu X, Zhang A, Guo C, Huang Z, He Y.
    Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation.
    Nat Commun 14(1):1012, 2023.
    https://doi.org/10.1038/s41467-023-36575-0
  • Cheng Y, Manabe I, Hayakawa S, Endo Y, Oishi Y.
    Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages.
    Front Immunol 14:1009973, 2023.
    https://doi.org/10.3389/fimmu.2023.1009973
  • Ohue-Kitano R, Nonaka H, Nishida A, Masujima Y, Takahashi D, Ikeda T, Uwamizu A, Tanaka M, Kohjima M, Igarashi M, Katoh H, Tanaka T, Inoue A, Suganami T, Hase K, Ogawa Y, Aoki J, Kimura I.
    Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84.
    JCI Insight 8(2):e165469, 2023.
    https://doi.org/10.1172/jci.insight.165469
  • Miyamoto J, Shimizu H, Hisa K, Matsuzaki C, Inuki S, Ando Y, Nishida A, Izumi A, Yamano M, Ushiroda C, Irie J, Katayama T, Ohno H, Itoh H, Yamamoto K, Kimura I.
    Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides.
    Gut Microbes 15(1):2161271, 2023.
    https://doi.org/10.1080/19490976.2022.2161271
  • Ono Y, Kawakami K, Nakamura G, Ishida S, Aoki J, Inoue A.
    Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs.
    Commun Biol 6(1):112, 2023.
    https://doi.org/10.1038/s42003-023-04465-2
  • Xu J, Wang Q, Hubner H, Hu Y, Niu X, Wang H, Maeda S, Inoue A, Tao Y, Gmeiner P, Du Y, Jin C, Kobilka BK.
    Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
    Nat Commun 14(1):376, 2023.
    https://doi.org/10.1038/s41467-022-35726-z
  • Tatsumi M, Kishi T, Ishida S, Kawana H, Uwamizu A, Ono Y, Kawakami K, Aoki J, Inoue A.
    Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.
    PLoS One 18(1):e0280448, 2023.
    https://doi.org/10.1371/journal.pone.0280448
  • Niizawa T, Sakuraba R, Kusaka T, Kurihara Y, Sugashi T, Kawaguchi H, Kanno I, Masamoto K.
    Spatiotemporal analysis of blood plasma and blood cell flow fluctuations of cerebral microcirculation in anesthetized rats.
    J Cereb Blood Flow Metab 43(1):138-152, 2023.
    https://doi.org/10.1177/0271678X221125743

総説

2022

原著論文

  • Hara K, Murakami M, Niitsu Y, Takeuchi A, Horino M, Shiba K, Tsujimoto K, Komiya C, Ikeda K, Tsuiki M, Tanabe A, Tanaka T, Yokoyama M, Fujii Y, Naruse M, Yamada T.
    Heterogeneous circulating miRNA profiles of PBMAH.
    Front Endocrinol (Lausanne) 13:1073328, 2022.
    https://doi.org/10.3389/fendo.2022.1073328
  • Nakamura Y, Yahiro T, Fukushima A, Kataoka N, Hioki H, Nakamura K.
    Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling.
    Sci Adv 8(51):eadd5463, 2022.
    https://doi.org/10.1126/sciadv.add5463
  • Kaneshige M, Obara K, Suzuki M, Tazoe T, Nishimura Y.
    Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys.
    Elife 11:e78346, 2022.
    https://doi.org/10.7554/eLife.78346
  • Umeda T, Isa T, Nishimura Y.
    Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement.
    Proc Natl Acad Sci U S A 119(48):e2208353119, 2022.
    https://doi.org/10.1073/pnas.2208353119
  • Nawaz A, Bilal M, Fujisaka S, Kado T, Aslam MR, Ahmed S, Okabe K, Igarashi Y, Watanabe Y, Kuwano T, Tsuneyama K, Nishimura A, Nishida Y, Yamamoto S, Sasahara M, Imura J, Mori H, Matzuk MM, Kudo F, Manabe I, Uezumi A, Nakagawa T, Oishi Y, Tobe K.
    Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration.
    Nat Commun 13(1):7058, 2022.
    https://doi.org/10.1038/s41467-022-34191-y
  • Hayakawa S, Tamura A, Nikiforov N, Koike H, Kudo F, Cheng Y, Miyazaki T, Kubekina M, Kirichenko TV, Orekhov AN, Yui N, Manabe I, Oishi Y.
    Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling.
    JCI Insight 7(22):e138539, 2022.
    https://doi.org/10.1172/jci.insight.138539
  • Janetzko J, Kise R, Barsi-Rhyne B, Siepe DH, Heydenreich FM, Kawakami K, Masureel M, Maeda S, Garcia KC, von Zastrow M, Inoue A, Kobilka BK.
    Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.
    Cell 185(24):4560-4573.e19, 2022.
    https://doi.org/10.1016/j.cell.2022.10.018
  • Kubo H, Sawada S, Satoh M, Asai Y, Kodama S, Sato T, Tomiyama S, Seike J, Takahashi K, Kaneko K, Imai J, Katagiri H.
    Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study.
    Sci Rep 12(1):20130, 2022.
    https://doi.org/10.1038/s41598-022-23521-1
  • Kohata M, Imai J, Izumi T, Yamamoto J, Kawana Y, Endo A, Sugawara H, Seike J, Kubo H, Komamura H, Sato T, Hosaka S, Munakata Y, Asai Y, Kodama S, Takahashi K, Kaneko K, Katagiri H.
    Roles of FoxM1-driven basal β-cell proliferation in maintenance of β-cell mass and glucose tolerance during adulthood.
    J Diabetes Investig 13(10):1666-1676, 2022.
    https://doi.org/10.1111/jdi.13846
  • Usuda N, Sugawara SK, Fukuyama H, Nakazawa K, Amemiya K, Nishimura Y.
    Quantitative comparison of corticospinal tracts arising from different cortical areas in humans.
    Neurosci Res 183:30-49, 2022.
    https://doi.org/10.1016/j.neures.2022.06.008
  • Suno R, Sugita Y, Morimoto K, Takazaki H, Tsujimoto H, Hirose M, Suno-Ikeda C, Nomura N, Hino T, Inoue A, Iwasaki K, Kato T, Iwata S, Kobayashi T.
    Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex.
    Cell Rep 40(11):111323, 2022.
    https://doi.org/10.1016/j.celrep.2022.111323
  • Walker AR, Larsen CB, Kundu S, Stavrinidis C, Kim SH, Inoue A, Woodward DF, Lee YS, Migale R, MacIntyre DA, Terzidou V, Fanelli F, Khanjani S, Bennett PR, Hanyaloglu AC.
    Functional rewiring of G protein-coupled receptor signaling in human labor.
    Cell Rep 40(10):111318, 2022.
    https://doi.org/10.1016/j.celrep.2022.111318
  • Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O.
    Endogenous ligand recognition and structural transition of a human PTH receptor.
    Mol Cell 82(18):3468-3483.e5, 2022.
    https://doi.org/10.1016/j.molcel.2022.07.003
  • Fukushima A, Kataoka N, Nakamura K.
    An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflows.
    Cell Rep 40(12):111380, 2022.
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    Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation.
    Front Hum Neurosci 16:1016064, 2022.
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    The ventral striatum contributes to the activity of the motor cortex and motor outputs in monkeys.
    Front Syst Neurosci 16:979272, 2022.
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  • Koba S, Kumada N, Narai E, Kataoka N, Nakamura K, Watanabe T.
    A brainstem circuit coordinating locomotor activities and sympathetic cardiovascular responses.
    Nat Commun 13(1):5079, 2022.
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  • Baidya M, Chaturvedi M, Dwivedi-Agnihotri H, Ranjan A, Devost D, Namkung Y, Stepniewski TM, Pandey S, Baruah M, Panigrahi B, Sarma P, Yadav MK, Maharana J, Banerjee R, Kawakami K, Inoue A, Selent J, Laporte SA, Hebert TE, Shukla AK.
    Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody.
    Nat Commun 13(1):4634, 2022.
    https://doi.org/10.1038/s41467-022-32386-x
  • Heo Y, Ishimoto N, Jeon YE, Yun JH, Ohki M, Anraku Y, Sasaki M, Kita S, Fukuhara H, Ikuta T, Kawakami K, Inoue A, Maenaka K, Tame JRH, Lee W, Park SY.
    Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.
    PLoS Biol 20(8):e3001714, 2022.
    https://doi.org/10.1371/journal.pbio.3001714
  • Nakayama Y, Sugawara SK, Fukunaga M, Hamano YH, Sadato N, Nishimura Y.
    The dorsal premotor cortex encodes the step-by-step planning processes for goal-directed motor behavior in humans.
    Neuroimage 256:119221, 2022.
    https://doi.org/10.1016/j.neuroimage.2022.119221
  • Ikegame S,Yoshimoto M, Miki K.
    Simultaneous measurement of central amygdala neuronal activity and sympathetic nerve activity during daily activities in rats.
    Exp Physiol 107(9):1071-1080, 2022.
    https://doi.org/10.1113/EP090538
  • Dixon AD, Inoue A, Robson SA, Culhane KJ, Trinidad JC, Sivaramakrishnan S, Bumbak F, Ziarek JJ.
    Effect of Ligands and Transducers on the Neurotensin Receptor 1 Conformational Ensemble.
    J Am Chem Soc 144(23):10241-10250, 2022.
    https://doi.org/10.1021/jacs.2c00828
  • Nureki I, Kobayashi K, Tanaka T, Demura K, Inoue A, Shihoya W, Nureki O.
    Cryo-EM structures of the β3 adrenergic receptor bound to solabegron and isoproterenol.
    Biochem Biophys Res Commun 611:158-164, 2022.
    https://doi.org/10.1016/j.bbrc.2022.04.065
  • Matic M, Singh G, Carli F, Oliveira Rosa N, Miglionico P, Magni L, Gutkind JS, Russell RB, Inoue A, Raimondi F.
    PRECOGx: exploring GPCR signaling mechanisms with deep protein representations.
    Nucleic Acids Res 50(W1):W598-W610, 2022.
    https://doi.org/10.1093/nar/gkac426
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    Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors.
    Proc Natl Acad Sci U S A 119(21):e2118847119, 2022.
    https://doi.org/10.1073/pnas.2118847119
  • Ninomiya T, Nakagawa H, Inoue KI, Nishimura Y, Oishi T, Yamashita T, Takada M.
    Origin of Multisynaptic Corticospinal Pathway to Forelimb Segments in Macaques and Its Reorganization After Spinal Cord Injury.
    Front Neural Circuits 16:847100, 2022.
    https://doi.org/10.3389/fncir.2022.847100
  • Miki K, Ikegame S, Yoshimoto M.
    Regional differences in sympathetic nerve activity are generated by multiple arterial baroreflex loops arranged in parallel.
    Front Physiol 13:858654, 2022.
    https://doi.org/10.3389/fphys.2022.858654
  • Nonaka H, Ohue-Kitano R, Masujima Y, Igarashi M, Kimura I.
    Dietary medium-chain triglyceride decanoate affects glucose homeostasis through GPR84-mediated GLP-1 secretion in mice.
    Front Nutr 9:e848450, 2022.
    https://doi.org/10.3389/fnut.2022.848450
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    A general model of hierarchical fractal scale-free networks.
    PLoS One 17(3):e0264589, 2022.
    https://doi.org/10.1371/journal.pone.0264589
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    Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes.
    Sci Signal 15(726):eabg5203, 2022.
    https://doi.org/10.1126/scisignal.abg5203
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    Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism.
    Nat Chem Biol 18(3):281-288, 2022.
    https://doi.org/10.1038/s41589-021-00930-3
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    VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes.
    Sci Rep 12(1):1377, 2022.
    https://doi.org/10.1038/s41598-022-05354-0
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    On a numerical bifurcation analysis of a particle reaction‐diffusion model for a motion of two self‐propelled disks.
    Jpn J Ind Appl Math 39:631-652, 2022.
    https://doi.org/10.1007/s13160-021-00498-4
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    Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias.
    Nat Commun 13(1):487, 2022.
    https://doi.org/10.1038/s41467-022-28056-7
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    Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.
    Bioorg Med Chem Lett 56:128485, 2022.
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総説

2021

原著論文

  • Pandey S, Kumari P, Baidya M, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li XX, Cui CS, Lee JD, Kawakami K, Chaturvedi M, Ranjan A, Laporte SA, Woodruff TM, Inoue A, Shukla AK.
    Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.
    Mol Cell 81(18):1-17, 2021.
    https://doi.org/10.1016/j.molcel.2021.09.007
  • Liu L, Koike H, Ono T, Hayashi S, Kudo F, Kaneda A, Kagechika H, Manabe I, Nakashima T, Oishi Y.
    Identification of a novel KLF5-dependent program and drug development for skeletal muscle atrophy.
    Proc Natl Acad Sci U S A 118(35):e2102895118, 2021.
    https://doi.org/10.1073/pnas.2102895118
  • Watanabe K, Yamano M, Masujima Y, Ohue-Kitano R, Kimura I.
    Curdlan intake changes gut microbial composition, short-chain fatty acid production, and bile acid transformation in mice.
    Biochem Biophys Rep 27:101095, 2021.
    https://doi.org/10.1016/j.bbrep.2021.101095
  • McGlone ER, Manchanda Y, Jones B, Pickford P, Inoue A, Carling D, Bloom SR, Tan T, Tomas A.
    Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.
    Mol Metab 53:101296, 2021.
    https://doi.org/10.1016/j.molmet.2021.101296
  • Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M, Crown SB, Osawa T, Sakai J, McGarrah RW, White PJ, Nakamura K, Kajimura S.
    Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever.
    Elife 10:e66865, 2021.
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  • Chiba H.
    A Hopf bifurcation in the Kuramoto-Daido model.
    J Diff Equ 280:545-570, 2021.
    https://doi.org/10.1016/j.jde.2021.01.024
  • Kubota SI, Takahashi K, Mano T, Matsumoto K, Katsumata T, Shi S, Tainaka K, Ueda HR, Ehata S, Miyazono K.
    Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing.
    Commun Biol 4(1):294, 2021.
    https://doi.org/10.1038/s42003-021-01786-y
  • Iwama T, Kano K, Saigusa D, Ekroos K, van Echten-Deckert G, Vogt J, Aoki J.
    Development of an On-Tissue Derivatization Method for MALDI Mass Spectrometry Imaging of Bioactive Lipids Containing Phosphate Monoester Using Phos-tag.
    Anal Chem 93(8):3867-3875, 2021.
    https://doi.org/10.1021/acs.analchem.0c04479
  • Adachi Y, Ota K, Minami I, Yamada T, Watanabe T.
    Lower Insulin Secretion Is Associated with Hippocampal and Parahippocampal Gyrus Atrophy in Elderly Patients with Type 2 Diabetes Mellitus.
    J Diabetes Investig 12(10):1908-1913, 2021.
    https://doi.org/10.1111/jdi.13554
  • Nakamaru R, Yamamoto K, Akasaka H, Rakugi H, Kurihara I, Yoneda T, Ichijo T, Katabami T, Tsuiki M, Wada N, Yamada T, Kobayashi H, Tamura K, Ogawa Y, Kawashima J, Inagaki N, Fujita M, Watanabe M, Kamemura K, Okamura S, Tanabe A, Naruse M; JPAS/JRAS Study Group.
    Age-stratified comparison of clinical outcomes between medical and surgical treatments in patients with unilateral primary aldosteronism.
    Sci Rep 11(1):6925, 2021.
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  • Kotani K, Akao A, Chiba H.
    Bifurcation of the neuronal population dynamics of the modified theta model: transition to macroscopic gamma oscillation.
    Physica D 416:132789, 2021.
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  • Fukuda T, Bouchi R, Takeuchi T, Amo-Shiinoki K, Kudo A, Tanaka S, Tanabe M, Akashi T, Hirayama K, Odamaki T, Igarashi M, Kimura I, Tanabe K, Tanizawa Y, Yamada T, Ogawa Y.
    Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes.
    Diabetes Care 44(4):1002-1011, 2021.
    https://doi.org/10.2337/dc20-0864
  • Nakamaru R, Yamamoto K, Akasaka H, Rakugi H, Kurihara I, Yoneda T, Ichijo T, Katabami T, Tsuiki M, Wada N, Yamada T, Kobayashi H, Tamura K, Ogawa Y, Kawashima J, Inagaki N, Fujita M, Oki K, Kamemura K, Tanabe A, Naruse M; JPAS/JRAS study group.
    Sex Differences in Renal Outcomes After Medical Treatment for Bilateral Primary Aldosteronism.
    Hypertension 77(2):537-545, 2021.
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  • Kano K, Matsumoto H, Kono N, Kurano M, Yatomi Y, Aoki J.
    Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification.
    J Lipid Res 62:100029, 2021.
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  • Amo-Shiinoki K, Tanabe K, Hoshii Y, Matsui H, Harano R, Fukuda T, Takeuchi T, Bouchi R, Takagi T, Hatanaka M, Takeda K, Okuya S, Nishimura W, Kudo A, Tanaka S, Tanabe M, Akashi T, Yamada T, Ogawa Y, Ikeda E, Nagano H, Tanizawa Y.
    Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes.
    JCI Insight 6(1):e143791, 2021.
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  • Bouchi R, Sonoda N, Itoh J, Ono Y, Fukuda T, Takeuchi T, Kishimoto J, Yamada T, Ogawa Y.
    Effects of intensive exercise combined with dapagliflozin on body composition in patients with type 2 diabetes: a randomized controlled trial.
    Endocr J 68(3):329-343, 2021.
    https://doi.org/10.1507/endocrj.EJ20-0599

総説

論評

2020

原著論文

  • Kawahori K, Kondo Y, Yuan X, Kawasaki Y, Hanzawa N, Tsujimoto K, Wada F, Kohda T, Ishigami A, Yamada T, Ogawa Y, Hashimoto K.
    Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver.
    Sci Rep 10(1):21228, 2020.
    https://doi.org/10.1038/s41598-020-77962-7

ムーンショット型研究開発事業 目標2:2050年までに超早期に疾患の予測・予防をすることができる社会を実現
恒常性の理解と制御による糖尿病および併発疾患の克服
プロジェクトマネージャー(PM):片桐秀樹(東北大学大学院医学系研究科 教授)
プロジェクトに関する問い合わせ先: moonshot-katagiri@proj.med.tohoku.ac.jp

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