Project Manager
Hideki Katagiri
Professor, Tohoku University
Graduate School of Medicine
In this moonshot project, we aim to realize a society, by 2050, in which diabetes and its complications can be easily detected at a very early stage, allowing reversal of these disease conditions. To achieve this goal, we are actively collaborating with researchers in various fields, encompassing not only many areas of medical science but also pharmacology, information science, engineering, and mathematics. We are conducting research to elucidate the mechanisms that maintain homeostasis at the whole-body level, focusing on inter-organ communication, to define the very early stages of diabetes and its complications, to develop simple detection methods, and to devise optimally effective remedial strategies.
News & Topics
- 2025.4.30
- Achievements for FY2024 have been updated.
- 2024.10.22
- Achievements for FY2024 have been updated.
- 2024.4.26
- Achievements for FY2023 have been updated.
- 2024.3.7
- [Press Release] Nakamura Group's research result "Researchers discovered the mechanism of middle-aged obesity: A major step toward innovative prevention and treatment of lifestyle-related diseases" has been released. For press release, click here. For the paper, click here.
- 2024.1.19
- [Press Release] Yamada Group's research result "Single-Nucleus Analysis Reveals Tumor Heterogeneity of Aldosterone-Producing Adenoma" has been released. For EurekAlert!, click here. For press release, click here. For the paper, click here.
- 2023.12.5
- [Press Release] Katagiri Group's research result "Stimulating Nerves Connected to the Pancreas Regenerates Insulin-Producing Cells" has been released. For press release, click here. For the paper, click here.
- 2023.9.19
- [Press Release] Katagiri Group's research result "Phagocytosis by macrophages promotes pancreatic β cell mass reduction after parturition in mice" has been released. For press release, click here. For the paper, click here.
- 2023.7.4
- [Press Release] Nakamura Group's research result "Researchers discovered two separate brain neural pathways for avoidance of hot and cold environments" has been released. For press release, click here. For the paper, click here.
- 2023.6.28
- Achievements for FY2023 have been updated.
- 2023.6.21
- Nakamura Group's original paper "Two Ascending Thermosensory Pathways from the Lateral Parabrachial Nucleus That Mediate Behavioral and Autonomous Thermoregulation" has been published online in J Neurosci.
- 2023.6.14
- [Press Release] Katagiri Group's research result "A highly sensitive strategy for monitoring real-time proliferation of targeted cell types in vivo" has been released. For press release, click here. For the paper, click here.
- 2023.4.28
- Katagiri Group's original paper "Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages" has been published online in Cell Rep.
- 2023.4.26
- Achievements for FY2022 have been updated.
- 2023.4.3
- Dr. Jun Takayama of Tohoku University and Dr. Yutaka Hasegawa of Iwate Medical University have joined the project as new principal investigators.
- R&D Group 5 was added.
- 2022.12.26
- [Press Release] Nakamura Group's research result "Researchers identified "master neurons" for body temperature regulation" has been released. For press release, click here. For the paper, click here.
- 2022.12.1
- Katagiri Group's original paper "Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study" was published in Sci Rep.
- 2022.11.21
- Achievements for FY2022 have been updated.
- 2022.9.21
- [Press Release] Nakamura Group's research result "Researchers discovered brain neural pathway for the "love hormone" oxytocin to burn fat" has been released. For press release, click here. For the paper, click here.
- 2022.9.8
- Kimura Group's review "Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases" has been published online in Pharmacol Ther.
- 2022.8.19
- Yoshimoto Group's original paper "Simultaneous measurement of central amygdala neuronal activity and sympathetic nerve activity during daily activities in rats" has been published online in Exp Physiol.
- 2022.4.28
- Achievements for FY2021 have been updated.
- 2022.4.28
- Project Manager Katagiri's review article "Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation" was published in Int Immunol.
- 2022.4.1
- Dr. Rikuhiro Yamada of RIKEN has joined the project as a new principal investigator.
- 2022.3.31
- Kimura Group's original paper "Dietary medium-chain triglyceride decanoate affects glucose homeostasis through GPR84-mediated GLP-1 secretion in mice" has been published online in Front Nutr.
- 2022.3.29
- Dr. Yuka Fujiki's (Chiba Group) original paper "A general model of hierarchical fractal scale-free networks" has been published online in PLoS One.
- 2022.3.26
- Moonshot Goal 2 Public Symposium 2022 "From Cure to Prevention" was held.
- 2021.11.26
- Nakamura Group's review "Central sympathetic network for thermoregulatory responses to psychological stress" has been published online in Auton Neurosci.
- 2021.11.25
- Website is now open!
- 2021.3.20
- Moonshot Goal 2 Kick-off Symposium was held.
