The aim of this project is to detect individuals with the ultra-early stages of diabetes or its co-morbidities non-invasively and to develop preventive/therapeutic strategies. To this end, research will be carried out in close collaboration within and among the following R&D Groups.

Group 1: Elucidation of homeostatic mechanisms by inter-organ communication and development of therapeutic and diagnostic methods

We will elucidate the inter-organ communication mechanisms maintaining homeostasis at the whole-body level related to metabolism and circulation.

Group 2: Elucidation and control of the mechanism of multi-organ transformation in diabetes mellitus

Diabetes mellitus is caused by and causes alterations in multiple organs. In the heart, liver, brain, kidney, and other organs and blood vessels, we will analyze both functional and morphological alterations in multiple organs/tissues in relation to inflammatory systems.

Group 3: Development of technology for easy acquisition of biometric data in humans and analysis of human data

Diabetes and co-morbidities are often asymptomatic, especially in the early stages of the disease. We aim to develop and implement methods for detecting and predicting the early stages of diabetes and its co-morbidities non-invasively and to analyze the obtained biometric data including the genome.

Group 4: Understanding homeostasis through mathematical model analysis and its applications

Using the data obtained from Groups 1, 2, 3, and 5, we will proceed with mathematical model analysis and extract key elements to gain a comprehensive understanding.

Group 5: Understanding the pre-symptomatic stage of diabetes and its complications and building a database

Collection of various data on the transition from normal to diseased state over time using laboratory animals, with the aim of constructing a pre-symptomatic stage database.